Rabbit anti-human Cystatin-C protein polyclonal Antibody, FITC conjugated | MyBioSource MBS715257 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Cystatin-C protein polyclonal Antibody, FITC conjugated

catalog :

MBS715257

quantity :

0.1 mg

price :

235 USD

clonality :

polyclonal

host :

rabbit

conjugate :

FITC

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS715257

products type :

Antibody

products full name :

Rabbit anti-human Cystatin-C protein polyclonal Antibody, FITC conjugated

products short name :

Cystatin-C protein

other names :

cystatin-C; Cystatin-C; cystatin-C; cystatin 3; cystatin-3; gamma-trace; post-gamma-globulin; bA218C14.4 (cystatin C); neuroendocrine basic polypeptide; cystatin C; Cystatin-3; Gamma-trace; Neuroendocrine basic polypeptide; Post-gamma-globulin

other gene names :

CST3; CST3; ARMD11

uniprot entry name :

CYTC_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

146

purity :

Caprylic Acid Ammonium Sulfate Precipitation

form :

Liquid

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

Western Blot (WB), ELISA (EIA)

other info1 :

Immunogen: Recombinant human Cystatin-C protein. Relevance: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity.

other info2 :

Storage Buffer: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 . Conjugate: FITC conjugated

ncbi gi num :

4503107

ncbi acc num :

NP_000090.1

ncbi gb acc num :

NM_000099.3

uniprot acc num :

P01034

ncbi mol weight :

15,799 Da

ncbi pathways :

Amyloids Pathway (366238); Disease Pathway (530764); Integrated Pancreatic Cancer Pathway (711360); Salivary Secretion Pathway (153376); Salivary Secretion Pathway (153352)

ncbi summary :

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Dec 2013]

uniprot summary :

CST3: As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Defects in CST3 are the cause of amyloidosis type 6 (AMYL6); also known as hereditary cerebral hemorrhage with amyloidosis (HCHWA), cerebral amyloid angiopathy (CAA) or cerebroarterial amyloidosis Icelandic type. AMYL6 is a hereditary generalized amyloidosis due to cystatin C amyloid deposition. Cystatin C amyloid accumulates in the walls of arteries, arterioles, and sometimes capillaries and veins of the brain, and in various organs including lymphoid tissue, spleen, salivary glands, and seminal vesicles. Amyloid deposition in the cerebral vessels results in cerebral amyloid angiopathy, cerebral hemorrhage and premature stroke. Cystatin C levels in the cerebrospinal fluid are abnormally low. Genetic variations in CST3 are associated with age- related macular degeneration type 11 (ARMD11). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the cystatin family. Protein type: Secreted; Inhibitor; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 20p11.21. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; protease binding; beta-amyloid binding; endopeptidase inhibitor activity; cysteine protease inhibitor activity. Biological Process: negative regulation of proteolysis; fibril organization and biogenesis; negative regulation of peptidase activity; defense response; regulation of tissue remodeling. Disease: Macular Degeneration, Age-related, 11; Cerebral Amyloid Angiopathy, Cst3-related

size1 :

0.1 mg

price1 :

235 USD

more info or order :

MyBioSource product webpage