Rabbit anti-human Superoxide dismutase [Cu-Zn] polyclonal Antibody, Biotin conjugated | MyBioSource MBS715205 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Superoxide dismutase [Cu-Zn] polyclonal Antibody, Biotin conjugated

catalog :

MBS715205

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS715205

products type :

Antibody

products full name :

Rabbit anti-human Superoxide dismutase [Cu-Zn] polyclonal Antibody, Biotin conjugated

products short name :

Superoxide dismutase [Cu-Zn]

products name syn :

Superoxide dismutase 1; hSod1

other names :

superoxide dismutase; Superoxide dismutase [Cu-Zn]; superoxide dismutase [Cu-Zn]; superoxide dismutase 1, soluble; Superoxide dismutase 1; hSod1

other gene names :

SOD1; SOD1; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer; hSod1

uniprot entry name :

SODC_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

154

purity :

Caprylic Acid Ammonium Sulfate Precipitation Purified

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

Western Blot (WB), ELISA (EIA)

other info1 :

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Biotin

other info2 :

Immunogen: Recombinant human Superoxide dismutase [Cu-Zn] protein

products description :

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

ncbi gi num :

4507149

ncbi acc num :

NP_000445.1

ncbi gb acc num :

NM_000454.4

uniprot acc num :

P00441

ncbi mol weight :

15,936 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Amyotrophic Lateral Sclerosis (ALS) Pathway (920975); Amyotrophic Lateral Sclerosis (ALS) Pathway (83099); Amyotrophic Lateral Sclerosis (ALS) Pathway (511); Cellular Responses To Stress Pathway (1270414); Detoxification Of Reactive Oxygen Species Pathway (1270420); Dopamine Metabolism Pathway (920995); FOXA1 Transcription Factor Network Pathway (137979); Folate Metabolism Pathway (198833); Hemostasis Pathway (1269340)

ncbi summary :

The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

SOD1: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family. Protein type: Mitochondrial; Nuclear receptor co-regulator; Apoptosis; Oxidoreductase; EC 1.15.1.1. Chromosomal Location of Human Ortholog: 21q22.11. Cellular Component: cell soma; cytoplasm; cytoplasmic vesicle; cytosol; dendrite cytoplasm; extracellular matrix; extracellular region; extracellular space; lysosome; mitochondrial intermembrane space; mitochondrial matrix; mitochondrion; myelin sheath; nucleoplasm; nucleus; peroxisome; plasma membrane; protein complex. Molecular Function: chaperone binding; copper ion binding; identical protein binding; protein binding; protein homodimerization activity; protein phosphatase 2B binding; Rac GTPase binding; superoxide dismutase activity; zinc ion binding. Biological Process: activation of MAPK activity; anterograde axon cargo transport; auditory receptor cell stereocilium organization and biogenesis; blood coagulation; cell aging; cellular iron ion homeostasis; embryo implantation; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; muscle maintenance; myelin maintenance in the peripheral nervous system; myeloid cell homeostasis; negative regulation of cholesterol biosynthetic process; negative regulation of neuron apoptosis; neurofilament cytoskeleton organization and biogenesis; ovarian follicle development; placenta development; platelet activation; platelet degranulation; positive regulation of apoptosis; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of superoxide release; regulation of blood pressure; regulation of GTPase activity; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; regulation of organ growth; regulation of protein kinase activity; regulation of T cell differentiation in the thymus; relaxation of vascular smooth muscle; removal of superoxide radicals; response to amphetamine; response to antibiotic; response to axon injury; response to copper ion; response to drug; response to ethanol; response to heat; response to hydrogen peroxide; response to nutrient levels; response to organic substance; response to reactive oxygen species; response to superoxide; retinal homeostasis; retrograde axon cargo transport; sensory perception of sound; spermatogenesis; superoxide metabolic process; superoxide release; thymus development; transmission of nerve impulse. Disease: Amyotrophic Lateral Sclerosis 1

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage