catalog number :
MBS715029
products full name :
Rabbit anti-human 14-3-3 protein beta/alpha polyclonal Antibody, FITC conjugated
products short name :
14-3-3 protein beta/alpha
other names :
14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha; 14-3-3 alpha; protein 1054; epididymis secretory protein Li 1; brain protein 14-3-3, beta isoform; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
other gene names :
YWHAB; YWHAB; HS1; GW128; YWHAA; KCIP-1; HEL-S-1; KCIP-1
uniprot entry name :
1433B_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Caprylic Acid Ammonium Sulfate Precipitation Purified
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
Western Blot (WB), ELISA (EIA)
other info1 :
Immunogen: Recombinant human 14-3-3 protein beta/alpha protein. Relevance: Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf 1 kinase activity and phosphorylation amoung many other functions.
other info2 :
Storage Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
. Conjugate: FITC conjugated
ncbi acc num :
NP_003395.1
ncbi gb acc num :
NM_003404.4
ncbi mol weight :
27,850 Da
ncbi pathways :
ARMS-mediated Activation Pathway 106466!!Activation Of BAD And Translocation To Mitochondria Pathway 105659!!Activation Of BH3-only Proteins Pathway 105658!!Adaptive Immune System Pathway 366160!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Apoptosis Pathway 105648!!Axon Guidance Pathway 105688!!Butyrate Response Factor 1 (BRF1) Destabilizes MRNA Pathway 187213!!Calcium Regulation In The Cardiac Cell Pathway 198906!!Cell Cycle Pathway 198811
ncbi summary :
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]