catalog number :
MBS715009
products full name :
Rabbit anti-human U1 small nuclear ribonucleoprotein A polyclonal Antibody
products short name :
U1 small nuclear ribonucleoprotein A
products name syn :
U1 snRNP A; U1-A; U1A
other names :
U1 small nuclear ribonucleoprotein A; U1 small nuclear ribonucleoprotein A; U1 small nuclear ribonucleoprotein A; small nuclear ribonucleoprotein polypeptide A
products gene name :
SNRPA
other gene names :
SNRPA; SNRPA; U1A; Mud1; U1-A; U1 snRNP A; U1-A; U1A
uniprot entry name :
SNRPA_HUMAN
purity :
Caprylic Acid Ammonium Sulfate Precipitation Purified
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
ELISA (EIA), Immunohistochemistry (IHC)
other info1 :
Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Non-conjugated
other info2 :
Immunogen: Recombinant human U1 small nuclear ribonucleoprotein A protein
products description :
Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process.
ncbi acc num :
NP_004587.1
ncbi gb acc num :
NM_004596.4
ncbi mol weight :
31,280 Da
ncbi pathways :
Gene Expression Pathway (1269649); Processing Of Capped Intron-Containing Pre-mRNA Pathway (1269688); Spliceosome Pathway (125136); Spliceosome Pathway (124832); Spliceosome, U1-snRNP Pathway (413435); Spliceosome, U1-snRNP Pathway (890598); MRNA Splicing Pathway (1269689); MRNA Splicing - Major Pathway (1269690); MRNA Processing Pathway (198843)
ncbi summary :
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]