Rabbit anti-human SET nuclear oncogene polyclonal Antibody | MyBioSource MBS714835 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human SET nuclear oncogene polyclonal Antibody

catalog :

MBS714835

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS714835

products type :

Antibody

products full name :

Rabbit anti-human SET nuclear oncogene polyclonal Antibody

products short name :

SET nuclear oncogene

products name syn :

SET nuclear oncogene; SET; 2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII; TAF-I; TAF-IBETA

other names :

SET nuclear oncogene; Protein SET; protein SET; SET nuclear oncogene; HLA-DR-associated protein II; phosphatase 2A inhibitor I2PP2A; inhibitor-2 of protein phosphatase-2A; protein phosphatase type 2A inhibitor; inhibitor of granzyme A-activated DNase; SET translocation (myeloid leukemia-associated); Template-Activating Factor-I, chromatin remodelling factor; SET nuclear proto-oncogene; HLA-DR-associated protein II; Inhibitor of granzyme A-activated DNase; IGAAD; PHAPII; Phosphatase 2A inhibitor I2PP2A; I-2PP2A; Template-activating factor I; TAF-I

other gene names :

SET; SET; 2PP2A; IGAAD; TAF-I; I2PP2A; IPP2A2; PHAPII; TAF-IBETA; IGAAD; I-2PP2A; TAF-I

uniprot entry name :

SET_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

277

purity :

Antigen Affinity Purified

tested application :

ELISA (EIA), Western Blot (WB)

other info1 :

Immunogen: Human SET

other info2 :

Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

ncbi gi num :

21618461

ncbi acc num :

AAH32749.1

ncbi mol weight :

31,404 Da

ncbi pathways :

Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Condensation Of Prophase Chromosomes Pathway (941401); Gene Expression Pathway (105937); HuR Stabilizes MRNA Pathway (187216); M Phase Pathway (105812); Mitotic Prophase Pathway (105813); Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway (187211)

ncbi summary :

The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

uniprot summary :

SET: a potent inhibitor of protein phosphatase 2A involved in apoptosis, transcription, nucleosome assembly and histone binding. The translocation t(6;9)(q21;q34.1) NUP214/CAN is found in some cases of acute undifferentiated leukemia (AUL). Two alternatively spliced isoforms have been described. Isoform 1 and isoform 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. Both isoforms inhibit the acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Protein type: Apoptosis; Inhibitor; DNA replication; Oncoprotein; Nuclear receptor co-regulator; DNA-binding. Chromosomal Location of Human Ortholog: 9q34. Cellular Component: nucleoplasm; protein complex; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleus. Molecular Function: protein binding; DNA binding; histone binding; protein phosphatase type 2A regulator activity; protein phosphatase inhibitor activity. Biological Process: nucleosome assembly; nucleosome disassembly; regulation of catalytic activity; negative regulation of catalytic activity; gene expression; nucleocytoplasmic transport; negative regulation of neuron apoptosis; mitotic cell cycle; negative regulation of transcription, DNA-dependent; DNA replication; negative regulation of histone acetylation

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage