Rabbit anti-human alkaline phosphatase, liver/bone/kidney polyclonal Antibody | MyBioSource MBS714524 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human alkaline phosphatase, liver/bone/kidney polyclonal Antibody

catalog :

MBS714524

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS714524

products type :

Antibody

products full name :

Rabbit anti-human alkaline phosphatase, liver/bone/kidney polyclonal Antibody

products short name :

alkaline phosphatase

products name syn :

alkaline phosphatase; liver/bone/kidney; ALPL; AP-TNAP; FLJ40094; FLJ93059; HOPS; MGC161443; MGC167935; TNAP; TNSALP

other names :

alkaline phosphatase; Alkaline phosphatase, tissue-nonspecific isozyme; alkaline phosphatase, tissue-nonspecific isozyme; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase liver/bone/kidney isozyme; alkaline phosphatase, liver/bone/kidney; Alkaline phosphatase liver/bone/kidney isozyme

other gene names :

ALPL; ALPL; HOPS; TNAP; APTNAP; TNSALP; AP-TNAP; AP-TNAP; TNSALP

uniprot entry name :

PPBT_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human,Mouse,Rat; Other species are not tested. Please decide the specificity by homology.

sequence length :

524

purity :

Antigen Affinity Purified

form :

Liquid

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

ELISA: Use at an assay dependent dilution. WB : 1:500-1:5000 . IHC : 1:20-1:200 (Recommender dilutions) . Positive WB detected in : HEK-293 cells, HeLa cells . Positive IHC detected in : Human colon cancer tissue, human liver cancer tissue, human lung cancer tissue . Positive FC detected in : HeLa cells

other info1 :

Immunogen: Human ALPL. Conjugate : Non-conjugated

other info2 :

Storage Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

products description :

Rabbit polyclonal to ALPL . This isozyme may play a role in skeletal mineralization.

ncbi gi num :

178462

ncbi acc num :

AAB59378.1

ncbi mol weight :

51,045 Da

ncbi pathways :

AGE/RAGE Pathway (698754); BDNF Signaling Pathway (712093); Endochondral Ossification Pathway (198812); Folate Biosynthesis Pathway (83018); Folate Biosynthesis Pathway (404); Metabolic Pathways (132956); TNF-alpha/NF-kB Signaling Pathway (198884)

ncbi summary :

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

uniprot summary :

ALPL: This isozyme may play a role in skeletal mineralization. Defects in ALPL are a cause of hypophosphatasia (HOPS). HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto). Defects in ALPL are a cause of hypophosphatasia childhood type (HOPSC). Defects in ALPL are a cause of hypophosphatasia infantile type (HOPSI). Belongs to the alkaline phosphatase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Cofactor and Vitamin Metabolism - folate biosynthesis; Motility/polarity/chemotaxis; EC 3.1.3.1; Membrane protein, GPI anchor; Phosphatase (non-protein). Chromosomal Location of Human Ortholog: 1p36.12. Cellular Component: extracellular matrix; extracellular space; membrane; plasma membrane; integral to membrane. Molecular Function: pyrophosphatase activity; protein binding; alkaline phosphatase activity; metal ion binding. Biological Process: response to antibiotic; osteoblast differentiation; response to vitamin D; dephosphorylation; response to glucocorticoid stimulus; reproductive developmental process; response to lipopolysaccharide; skeletal development; endochondral ossification. Disease: Hypophosphatasia, Infantile; Hypophosphatasia, Adult; Hypophosphatasia, Childhood

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage