catalog number :
MBS714352
products full name :
Rabbit anti-human toll-interleukin 1 receptor (TIR) domain containing adaptor protein polyclonal Antibody
products short name :
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
products name syn :
toll-interleukin 1 receptor (TIR) domain containing adaptor protein; TIRAP; FLJ42305; Mal; wyatt
other names :
toll-interleukin 1 receptor (TIR) domain containing adaptor protein, isoform CRA_b; Toll/interleukin-1 receptor domain-containing adapter protein; toll/interleukin-1 receptor domain-containing adapter protein; adapter protein wyatt; adaptor protein Wyatt; MyD88 adapter-like protein; Toll-like receptor adaptor protein; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Adaptor protein Wyatt; MyD88 adapter-like protein; MyD88-2
other gene names :
TIRAP; TIRAP; Mal; wyatt; BACTS1; MyD88-2; MAL; TIR domain-containing adapter protein; MyD88-2
uniprot entry name :
TIRAP_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human TIRAP
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
EAW67689.1
ncbi mol weight :
27,948 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!Activated TLR4 Signalling Pathway 106400!!Hepatitis B Pathway 694606!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!MyD88:Mal Cascade Initiated On Plasma Membrane Pathway 106390!!NF-kappa B Signaling Pathway 634527!!Pertussis Pathway 218111!!Pertussis Pathway 218099!!Regulation Of Toll-like Receptor Signaling Pathway 920955
ncbi summary :
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]