Rabbit anti-human adenosine deaminase, RNA-specific polyclonal Antibody | MyBioSource MBS714315 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human adenosine deaminase, RNA-specific polyclonal Antibody

catalog :

MBS714315

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS714315

products type :

Antibody

products full name :

Rabbit anti-human adenosine deaminase, RNA-specific polyclonal Antibody

products short name :

adenosine deaminase, RNA-specific

products name syn :

adenosine deaminase; RNA-specific; ADAR; ADAR1; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88dsRBP; p136

other names :

Adenosine deaminase, RNA-specific; Double-stranded RNA-specific adenosine deaminase; double-stranded RNA-specific adenosine deaminase; dsRNA adenosine deaminase; interferon-induced protein 4; interferon-inducible protein 4; adenosine deaminase acting on RNA 1-A; 136 kDa double-stranded RNA-binding protein; adenosine deaminase, RNA-specific; 136 kDa double-stranded RNA-binding protein; p136; Interferon-inducible protein 4; IFI-4; K88DSRBP

other gene names :

ADAR; ADAR; DSH; AGS6; G1P1; IFI4; P136; ADAR1; DRADA; DSRAD; IFI-4; K88DSRBP; ADAR1; DSRAD; G1P1; IFI4; DRADA; p136; IFI-4

uniprot entry name :

DSRAD_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat, Pig

sequence length :

1226

purity :

Antigen Affinity Purified

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

other info1 :

Immunogen: Human ADAR1

other info2 :

Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

ncbi gi num :

23398522

ncbi acc num :

AAH38227.1

ncbi mol weight :

103,642 Da

ncbi pathways :

C6 Deamination Of Adenosine Pathway (106580); Cytokine Signaling In Immune System Pathway (366171); Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Formation Of Editosomes By ADAR Proteins Pathway (106579); Gene Expression Pathway (105937); Immune System Pathway (106386); Influenza A Pathway (217173); Influenza A Pathway (217150); Interferon Signaling Pathway (187103)

ncbi summary :

This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

uniprot summary :

ADAR: Converts multiple adenosines to inosines and creates I/U mismatched base pairs in double-helical RNA substrates without apparent sequence specificity. Has been found to modify more frequently adenosines in AU-rich regions, probably due to the relative ease of melting A/U base pairs as compared to G/C pairs. Functions to modify viral RNA genomes and may be responsible for hypermutation of certain negative-stranded viruses. Edits the messenger RNAs for glutamate receptor (GLUR) subunits by site- selective adenosine deamination. Produces low-level editing at the GLUR-B Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference. Binds to ILF3/NF90 and up-regulates ILF3-mediated gene expression. Isoform 1 is induced by interferon alpha. Isoform 5 is constitutively expressed. Homodimer. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. 5 isoforms of the human protein are produced by alternative promoter. Protein type: Hydrolase; EC 3.5.4.37; RNA-binding; RNA processing; Nucleolus. Chromosomal Location of Human Ortholog: 1q21.3. Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nucleus. Molecular Function: double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; metal ion binding. Biological Process: positive regulation of viral genome replication; base conversion or substitution editing; in utero embryonic development; response to virus; cytokine and chemokine mediated signaling pathway; miRNA-mediated gene silencing, miRNA loading onto RISC; somatic diversification of immune receptors via somatic mutation; adenosine to inosine editing; osteoblast differentiation; negative regulation of viral genome replication; protein import into nucleus; pre-microRNA processing; mRNA modification; erythrocyte differentiation; innate immune response; gene expression; hemopoietic progenitor cell differentiation; protein export from nucleus; mRNA processing; defense response to virus; negative regulation of apoptosis. Disease: Dyschromatosis Symmetrica Hereditaria; Aicardi-goutieres Syndrome 6

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage