Rabbit anti-human purinergic receptor P2Y, G-protein coupled, 1 polyclonal Antibody | MyBioSource MBS714249 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human purinergic receptor P2Y, G-protein coupled, 1 polyclonal Antibody

catalog :

MBS714249

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS714249

products type :

Antibody

products full name :

Rabbit anti-human purinergic receptor P2Y, G-protein coupled, 1 polyclonal Antibody

products short name :

purinergic receptor P2Y, G-protein coupled, 1

products name syn :

purinergic receptor P2Y; G-protein coupled; 1; P2RY1; P2Y1

other names :

Purinergic receptor P2Y, G-protein coupled, 1; P2Y purinoceptor 1; P2Y purinoceptor 1; ATP receptor; platelet ADP receptor; P2 purinoceptor subtype Y1; purinergic receptor P2Y, G-protein coupled, 1; ATP receptor; Purinergic receptor

other gene names :

P2RY1; P2RY1; P2Y1; P2Y1

uniprot entry name :

P2RY1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human; Other species are not tested. Please decide the specificity by homology.

sequence length :

373

purity :

Antigen Affinity Purified

form :

Liquid

storage stability :

Shipped at 4 degree C Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

ELISA: Use at an assay dependent dilution . WB:1:500-1:2000. IHC : 1:20-1:200 (Recommender dilutions) . Positive WB detected in Jurkat cells. Positive IHC detected in Human testis

other info1 :

Immunogen: Human P2RY1. Conjugate: Non-conjugated

other info2 :

Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

products description :

Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

ncbi gi num :

50960812

ncbi acc num :

AAH74785.1

ncbi pathways :

ADP Signalling Through P2Y Purinoceptor 1 Pathway (161061); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Hemostasis Pathway (106028); Neuroactive Ligand-receptor Interaction Pathway (83053); Neuroactive Ligand-receptor Interaction Pathway (462)

ncbi summary :

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

uniprot summary :

P2RY1: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. Belongs to the G-protein coupled receptor 1 family. Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: 3q25.2. Cellular Component: postsynaptic membrane; cell surface; mitochondrion; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; dendrite; plasma membrane. Molecular Function: ATP-activated nucleotide receptor activity; protein binding; purinergic nucleotide receptor activity, G-protein coupled; protein heterodimerization activity; receptor activity; A1 adenosine receptor binding; ADP binding; ATP binding; ADP-activated nucleotide receptor activity. Biological Process: platelet activation; regulation of vasodilation; eating behavior; positive regulation of hormone secretion; positive regulation of inositol trisphosphate biosynthetic process; negative regulation of binding; sensory perception of pain; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; response to mechanical stimulus; positive regulation of transcription from RNA polymerase II promoter; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of ion transport; positive regulation of protein amino acid phosphorylation; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of receptor activity; blood coagulation; adenosine receptor signaling pathway; aging

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage