catalog number :
MBS714230
products full name :
Rabbit anti-human 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) polyclonal Antibody
products short name :
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
products name syn :
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMGCS1; HMGCS; MGC90332
other names :
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); Hydroxymethylglutaryl-CoA synthase, cytoplasmic; hydroxymethylglutaryl-CoA synthase, cytoplasmic; 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); 3-hydroxy-3-methylglutaryl coenzyme A synthase
other gene names :
HMGCS1; HMGCS1; HMGCS; HMGCS; HMG-CoA synthase
uniprot entry name :
HMCS1_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
other info1 :
Immunogen: Human HMGCS1
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAH83514.1
ncbi mol weight :
57,294 Da
ncbi pathways :
Activation Of Gene Expression By SREBF (SREBP) Pathway (685552); Butanoate Metabolism Pathway (83007); Butanoate Metabolism Pathway (391); C5 Isoprenoid Biosynthesis, Mevalonate Pathway (413387); C5 Isoprenoid Biosynthesis, Mevalonate Pathway (468288); Cholesterol Biosynthesis Pathway (198809); Cholesterol Biosynthesis Pathway (106142); Endochondral Ossification Pathway (198812); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977)
uniprot summary :
HMGCS1: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family. Protein type: Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.3.3.10; Transferase; Lipid Metabolism - synthesis and degradation of ketone bodies; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation. Chromosomal Location of Human Ortholog: 5p14-p13. Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol; nucleus. Molecular Function: protein homodimerization activity; organic acid binding; hydroxymethylglutaryl-CoA synthase activity; isomerase activity; drug binding. Biological Process: response to drug; response to purine; isoprenoid biosynthetic process; male gonad development; cellular lipid metabolic process; liver development; cholesterol biosynthetic process; response to low light intensity; response to vitamin E; response to tellurium ion; response to lipoprotein stimulus; brain development; lipid metabolic process