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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human Rho GTPase activating protein 24 polyclonal Antibody
catalog :
MBS714207
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS714207
products type :
Antibody
products full name :
Rabbit anti-human Rho GTPase activating protein 24 polyclonal Antibody
products short name :
Rho GTPase activating protein 24
products name syn :
Rho GTPase activating protein 24; ARHGAP24; DKFZp564B1162; FILGAP; FLJ33877; RC-GAP72; RCGAP72; p73; p73RhoGAPFILGAP
other names :
rho GTPase-activating protein 24 isoform 1; Rho GTPase-activating protein 24; rho GTPase-activating protein 24; rhoGAP of 73 kDa; sarcoma antigen NY-SAR-88; filamin-A-associated RhoGAP; rho-type GTPase-activating protein 24; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; Rho GTPase activating protein 24; Filamin-A-associated RhoGAP; FilGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RC-GAP72; Rho-type GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY-SAR-88; p73RhoGAP
other gene names :
ARHGAP24; ARHGAP24; p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP; FILGAP; FilGAP; RC-GAP72
uniprot entry name :
RHG24_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human,Mouse,Rat; Other species are not tested. Please decide the specificity by homology.
sequence length :
748
purity :
Antigen Affinity Purified
form :
Liquid
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human ARHGAP24. Conjugated: Non-conjugated
other info2 :
Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
products description :
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
ncbi gi num :
111154092
ncbi acc num :
NP_001020787.2
ncbi gb acc num :
NM_001025616.2
ncbi pathways :
Rho GTPase Cycle Pathway (106503); Signal Transduction Pathway (477114); Signaling By Rho GTPases Pathway (106502)
ncbi summary :
ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
uniprot summary :
ARHGAP24: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. 5 isoforms of the human protein are produced by alternative splicing. Protein type: GAPs; GAPs, Rac/Rho; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 4q22.1. Cellular Component: focal adhesion; cell projection; cytoskeleton; cytosol. Molecular Function: protein binding. Biological Process: negative regulation of Rac protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; angiogenesis; cell differentiation; wound healing, spreading of epidermal cells
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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