catalog number :
MBS713978
products full name :
Rabbit anti-human procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 polyclonal Antibody
products short name :
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
products name syn :
procollagen-lysine; 2-oxoglutarate 5-dioxygenase 2; PLOD2; LH2; TLH
other names :
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; lysyl hydroxlase 2; lysyl hydroxylase 2; lysine hydroxylase 2; telopeptide lysyl hydroxylase; procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; Lysyl hydroxylase 2; LH2
other gene names :
PLOD2; PLOD2; LH2; TLH; LH2
uniprot entry name :
PLOD2_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB)
other info1 :
Immunogen: Human PLOD2
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAH37169.1
ncbi mol weight :
87,098 Da
ncbi pathways :
Collagen Biosynthesis And Modifying Enzymes Pathway 645289!!Collagen Formation Pathway 645288!!Extracellular Matrix Organization Pathway 576262!!Lysine Degradation Pathway 82956!!Lysine Degradation Pathway 320
ncbi summary :
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]