Rabbit anti-human A kinase (PRKA) anchor protein 3 polyclonal Antibody | MyBioSource MBS713973 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human A kinase (PRKA) anchor protein 3 polyclonal Antibody

catalog :

MBS713973

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS713973

products type :

Antibody

products full name :

Rabbit anti-human A kinase (PRKA) anchor protein 3 polyclonal Antibody

products short name :

A kinase (PRKA) anchor protein 3

products name syn :

A kinase (PRKA) anchor protein 3; AKAP3; AKAP110; CT82; FSP95; PRKA3; SOB1

other names :

A-kinase anchor protein 9 isoform 3; A-kinase anchor protein 9; A-kinase anchor protein 9; protein yotiao; protein hyperion; AKAP 120-like protein; AKAP9-BRAF fusion protein; kinase N-associated protein; A-kinase anchor protein 350 kDa; A-kinase anchor protein 450 kDa; protein kinase A anchoring protein 9; A kinase (PRKA) anchor protein (yotiao) 9; protein phosphatase 1, regulatory subunit 45; centrosome- and Golgi-localized PKN-associated protein; centrosome- and golgi-localized protein kinase N-associated protein; A kinase (PRKA) anchor protein 9; A-kinase anchor protein 350 kDa; AKAP 350; hgAKAP 350; A-kinase anchor protein 450 kDa; AKAP 450; AKAP 120-like protein; Centrosome- and Golgi-localized PKN-associated protein; CG-NAP; Protein hyperion; Protein kinase A-anchoring protein 9; PRKA9; Protein yotiao

other gene names :

AKAP9; AKAP9; LQT11; PRKA9; AKAP-9; CG-NAP; YOTIAO; AKAP350; AKAP450; PPP1R45; HYPERION; MU-RMS-40.16A; AKAP350; AKAP450; KIAA0803; AKAP-9; AKAP 350; hgAKAP 350; AKAP 450; CG-NAP; PRKA9

uniprot entry name :

AKAP9_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

3899

purity :

Antigen Affinity Purified

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

other info1 :

Immunogen: Human AKAP3

other info2 :

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

ncbi gi num :

22538393

ncbi acc num :

NP_671714.1

ncbi gb acc num :

NM_147185.2

ncbi mol weight :

455,423 Da

ncbi pathways :

Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); CREB Phosphorylation Through The Activation Of CaMKII Pathway (161040); CREB Phosphorylation Through The Activation Of Ras Pathway (161036); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Centrosome Maturation Pathway (105807); G Protein Signaling Pathways (198849); G2/M Transition Pathway (105801); Loss Of Nlp From Mitotic Centrosomes Pathway (105811); Loss Of Proteins Required For Interphase Microtubule OrganizationÃ‚Â From The Centrosome Pathway (105810)

ncbi summary :

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq, Aug 2008]

uniprot summary :

AKAP9: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Defects in AKAP9 are the cause of long QT syndrome type 11 (LQT11). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 7q21-q22. Cellular Component: Golgi apparatus; centrosome; pericentriolar material; voltage-gated potassium channel complex; cytoskeleton; intracellular membrane-bound organelle; cytosol. Molecular Function: protein binding; potassium channel regulator activity; protein complex scaffold; receptor binding. Biological Process: synaptic transmission; transport; organelle organization and biogenesis; spermatogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; signal transduction; Sertoli cell development; positive regulation of peptidyl-serine phosphorylation. Disease: Long Qt Syndrome 11

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage