antibody

Rabbit anti-human guanylate cyclase 2D, membrane (retina-specific) polyclonal Antibody

MBS713936

0.05 mL

375 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

Rabbit anti-human guanylate cyclase 2D, membrane (retina-specific) polyclonal Antibody

guanylate cyclase 2D

guanylate cyclase 2D; membrane (retina-specific); GUCY2D; CORD5; CORD6; CYGD; GUC1A4; GUC2D; LCA; LCA1; RETGC-1; ROS-GC1; retGC

guanylate cyclase 2D, partial

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

3

Antigen Affinity Purified

ELISA (EIA), Western Blot (WB)

Immunogen: Human GUCY2D

Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

90110499

ABD90536.1

This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]

GUCY2D: Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. Defects in GUCY2D are the cause of Leber congenital amaurosis type 1 (LCA1). LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children. Defects in GUCY2D are the cause of cone-rod dystrophy type 6 (CORD6). CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Protein type: Protein kinase, dual-specificity (receptor); EC 4.6.1.2; Nucleotide Metabolism - purine; Protein kinase, RGC; Membrane protein, integral; Receptor, misc.; Kinase, protein; Lyase; Guanylyl cyclase; RGC group; RGC family. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: nuclear outer membrane; integral to plasma membrane. Molecular Function: guanylate cyclase activity; GTP binding; receptor activity; ATP binding; protein kinase activity. Biological Process: rhodopsin mediated signaling; cGMP biosynthetic process; phototransduction, visible light; regulation of rhodopsin mediated signaling; visual perception; receptor guanylyl cyclase signaling pathway; protein amino acid phosphorylation. Disease: Leber Congenital Amaurosis 1; Cone-rod Dystrophy 6

0.05 mL

375 USD

0.15 mL

715