Rabbit anti-human FXYD domain containing ion transport regulator 2 polyclonal Antibody | MyBioSource MBS713759 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human FXYD domain containing ion transport regulator 2 polyclonal Antibody

catalog :

MBS713759

quantity :

0.05 mL

price :

230 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS713759

products type :

Antibody

products full name :

Rabbit anti-human FXYD domain containing ion transport regulator 2 polyclonal Antibody

products short name :

[FXYD domain containing ion transport regulator 2]

products name syn :

[FXYD domain containing ion transport regulator 2; FXYD2; ATP1G1; HOMG2; MGC12372]

other names :

[FXYD domain containing ion transport regulator 2; Sodium/potassium-transporting ATPase subunit gamma; sodium/potassium-transporting ATPase subunit gamma; sodium pump gamma chain; Na(+)/K(+) ATPase subunit gamma; ATPase, Na+/K+ transporting, gamma 1 polypeptide; FXYD domain containing ion transport regulator 2; FXYD domain-containing ion transport regulator 2; Sodium pump gamma chain]

other gene names :

[FXYD2; FXYD2; HOMG2; ATP1G1; ATP1C; ATP1G1; Na(+)/K(+) ATPase subunit gamma]

uniprot entry name :

ATNG_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

purity :

Antigen Affinity Purified

form :

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3.

storage stability :

Upon receipt store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

other info1 :

Immunogen: Human FXYD2

other info2 :

Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26101

products description :

This gene encodes a member o f a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The Type III integral membrane protein encoded by this gene is the gamma subunit of the Na,K-ATPase present on the plasma membrane. Although the Na,K-ATPase does not depend on the gamma subunit to be functional, it is thought that the gamma subunit modulates the enzyme s activity by inducing ion channel activity. Mutations in this gene have been associated with renal hypomagnesaemia. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene.

ncbi gi num :

15342034

ncbi acc num :

AAH13289.1

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); Calcium Regulation In The Cardiac Cell Pathway (198906); Carbohydrate Digestion And Absorption Pathway (170720); Carbohydrate Digestion And Absorption Pathway (170654); Cardiac Muscle Contraction Pathway (93344)

ncbi summary :

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]

uniprot summary :

FXYD2: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. Defects in FXYD2 are the cause of hypomagnesemia type 2 (HOMG2); also known as dominant renal hypomagnesemia or hypomagnesemia with hypocalciuria. HOMG2 is a disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria. Belongs to the FXYD family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 11q23. Cellular Component: intracellular membrane-bound organelle; basolateral plasma membrane; plasma membrane; sodium:potassium-exchanging ATPase complex. Molecular Function: transporter activity; sodium:potassium-exchanging ATPase activity; ion channel activity. Biological Process: transport; regulation of cell growth; transmembrane transport; potassium ion transport; regulation of cell proliferation. Disease: Hypomagnesemia 2, Renal

size1 :

0.05 mL

price1 :

230 USD

size2 :

0.15 mL

price2 :

500

more info or order :

MyBioSource product webpage