catalog number :
MBS713706
products full name :
Rabbit anti-human placental growth factor polyclonal Antibody
products short name :
placental growth factor
products name syn :
placental growth factor; PGF; D12S1900; PGFL; PLGF; PlGF-2; SHGC-10760
other names :
Placental growth factor; Placenta growth factor; placenta growth factor; placental growth factor, vascular endothelial growth factor-related protein; placental growth factor
other gene names :
PGF; PGF; PGFL; PLGF; PlGF-2; D12S1900; SHGC-10760; PGFL; PLGF; PlGF
uniprot entry name :
PLGF_HUMAN
reactivity :
Human;Other species are not tested. Please decide the specificity by homology.
purity :
Antigen Affinity Purified
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
app notes :
ELISA: Use at an assay dependent dilution. WB : 1:200-1:2000. IP : 1:200-1:2000. IHC : 1:20-1:200 (Recommender dilutions). Positive WB detected in: MCF7 cells . Positive IP detected in: Human placenta tissue . Positive IHC detected in: Human placenta tissue, human breast cancer tissue, human meningioma tissue
other info1 :
Immunogen: Human PGF. Conjugate : Non-conjugated
other info2 :
Storage Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
products description :
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
ncbi acc num :
AAH07789.1
ncbi pathways :
Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979); Pathways In Cancer (83105); Rap1 Signaling Pathway (868086); Rap1 Signaling Pathway (878042); Ras Signaling Pathway (868085); Signal Transduction Pathway (477114)
ncbi summary :
This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]
uniprot summary :
PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 14q24.3. Cellular Component: extracellular space; membrane; extracellular region. Molecular Function: heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity. Biological Process: response to drug; positive regulation of angiogenesis; organ regeneration; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; female pregnancy; sprouting angiogenesis; signal transduction; cell differentiation; vascular endothelial growth factor receptor signaling pathway; cellular response to hormone stimulus