product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human Coenzyme A synthase polyclonal Antibody
catalog :
MBS713333
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS713333
products type :
Antibody
products full name :
Rabbit anti-human Coenzyme A synthase polyclonal Antibody
products short name :
Coenzyme A synthase
products name syn :
Coenzyme A synthase; COASY; DPCK; FLJ35179; NBP; PPAT; UKR1; pOV-2
other names :
Coenzyme A synthase; Bifunctional coenzyme A synthase; bifunctional coenzyme A synthase; nucleotide binding protein; phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase; bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase; CoA synthase; NBP; POV-2Including the following 2 domains:Phosphopantetheine adenylyltransferase (EC:2.7.7.3)Alternative name(s):Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT
other gene names :
COASY; COASY; NBP; DPCK; PPAT; UKR1; NBIA6; pOV-2; CoA synthase; PPAT; DPCK; DPCOAK
uniprot entry name :
COASY_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
564
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human COASY
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi gi num :
45501329
ncbi acc num :
AAH67254.1
ncbi mol weight :
65,339 Da
ncbi pathways :
Coenzyme A Biosynthesis Pathway (106255); Coenzyme A Biosynthesis, Pantothenate = CoA Pathway (413397); Coenzyme A Biosynthesis, Pantothenate = CoA Pathway (468312); Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway (906000); Defective BTD Causes Biotidinase Deficiency Pathway (906015); Defective CD320 Causes Methylmalonic Aciduria Pathway (906012); Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway (906001); Defective GIF Causes Intrinsic Factor Deficiency Pathway (906004); Defective HLCS Causes Multiple Carboxylase Deficiency Pathway (906014); Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway (906003)
ncbi summary :
Coenzyme A (CoA) functions as a carrier of acetyl and acyl groups in cells and thus plays an important role in numerous synthetic and degradative metabolic pathways in all organisms. In eukaryotes, CoA and its derivatives are also involved in membrane trafficking and signal transduction. This gene encodes the bifunctional protein coenzyme A synthase (CoAsy) which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this bifunctional protein catalyzes the conversion of 4'-phosphopantetheine into dephospho-coenzyme A (dpCoA) while its dephospho-CoA kinase domain completes the final step by phosphorylating dpCoA to form CoA. Mutations in this gene are associated with neurodegeneration with brain iron accumulation (NBIA). Alternative splicing results in multiple isoforms. [provided by RefSeq, Apr 2014]
uniprot summary :
PPAT: bifunctional cytoplasmic enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. Protein type: Transferase; EC 2.7.7.3; Kinase, other; EC 2.7.1.24; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis. Chromosomal Location of Human Ortholog: 17q12-q21. Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrial matrix; cytoplasm. Molecular Function: protein binding; dephospho-CoA kinase activity; pantetheine-phosphate adenylyltransferase activity; ATP binding. Biological Process: coenzyme A biosynthetic process; coenzyme biosynthetic process; vitamin metabolic process; pantothenate metabolic process; phosphorylation; water-soluble vitamin metabolic process. Disease: Neurodegeneration With Brain Iron Accumulation 6
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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