catalog number :
MBS713150
products full name :
Rabbit anti-human APEX nuclease (multifunctional DNA repair enzyme) 1 polyclonal Antibody
products short name :
APEX nuclease (multifunctional DNA repair enzyme) 1
products name syn :
APEX nuclease (multifunctional DNA repair enzyme) 1; APEX1; APE; APE1; APEN; APEX; APX; HAP1; REF1
other names :
APEX nuclease (multifunctional DNA repair enzyme) 1; DNA-(apurinic or apyrimidinic site) lyase; DNA-(apurinic or apyrimidinic site) lyase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase; protein REF-1; redox factor-1; AP endonuclease class I; apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic (abasic) endonuclease; deoxyribonuclease (apurinic or apyrimidinic); APEX nuclease (multifunctional DNA repair enzyme) 1; APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1Cleaved into the following chain:DNA-(apurinic or apyrimidinic site) lyase, mitochondrial
other gene names :
APEX1; APEX1; APE; APX; APE1; APEN; APEX; HAP1; REF1; APE; APE1; APEX; APX; HAP1; REF1; APEN; AP endonuclease 1; APE-1
uniprot entry name :
APEX1_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human APEX1
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAV38935.1
ncbi mol weight :
35,555 Da
ncbi pathways :
BER Complex Pathway 413429!!BER Complex Pathway 468377!!Base Excision Repair Pathway 105838!!Base Excision Repair Pathway 83043!!Base Excision Repair Pathway 451!!Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway 105848!!DNA Repair Pathway 105837!!Displacement Of DNA Glycosylase By APE1 Pathway 105849!!HIF-2-alpha Transcription Factor Network Pathway 137956!!Removal Of DNA Patch Containing Abasic Residue Pathway 105851
ncbi summary :
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]