catalog number :
MBS713107
products full name :
Rabbit anti-human damage-specific DNA binding protein 2, 48kDa polyclonal Antibody
products short name :
damage-specific DNA binding protein 2
other names :
DNA damage-binding protein 2 isoform D1; DNA damage-binding protein 2; DNA damage-binding protein 2; UV-DDB 2; DDB p48 subunit; UV-damaged DNA-binding protein 2; damage-specific DNA-binding protein 2; xeroderma pigmentosum group E protein; damage-specific DNA binding protein 2, 48kDa; DDB p48 subunit; DDBb; Damage-specific DNA-binding protein 2; UV-damaged DNA-binding protein 2; UV-DDB 2
other gene names :
DDB2; DDB2; DDBB; UV-DDB2; DDBb; UV-DDB 2
uniprot entry name :
DDB2_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA)
other info1 :
Immunogen: Human DDB2
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
NP_001287663.1
ncbi gb acc num :
NM_001300734.1
ncbi mol weight :
26,758 Da
ncbi pathways :
Cul4-DDB1-DDB2 Complex Pathway 413452!!Cul4-DDB1-DDB2 Complex Pathway 890608!!DNA Repair Pathway 105837!!DNA Damage Response Pathway 198788!!Direct P53 Effectors Pathway 137939!!Dual Incision Reaction In GG-NER Pathway 105887!!Formation Of Incision Complex In GG-NER Pathway 105886!!Global Genomic NER (GG-NER) Pathway 105884!!Hepatitis B Pathway 694606!!Nucleotide Excision Repair Pathway 105883
ncbi summary :
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]