product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human hydroxysteroid (17-beta) dehydrogenase 8 polyclonal Antibody
catalog :
MBS712872
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS712872
products type :
Antibody
products full name :
Rabbit anti-human hydroxysteroid (17-beta) dehydrogenase 8 polyclonal Antibody
products short name :
hydroxysteroid (17-beta) dehydrogenase 8
products name syn :
hydroxysteroid (17-beta) dehydrogenase 8; HSD17B8; D6S2245E; FABG; FABGL; H2-KE6; HKE6; KE6; RING2; SDR30C1; dJ1033B10.9
other names :
Hydroxysteroid (17-beta) dehydrogenase 8; Estradiol 17-beta-dehydrogenase 8; estradiol 17-beta-dehydrogenase 8; ke-6; protein Ke6; 17-beta-HSD 8; estrogen 17-oxidoreductase; testosterone 17-beta-dehydrogenase 8; really interesting new gene 2 protein; 17-beta-hydroxysteroid dehydrogenase 8; 3-oxoacyl-[acyl-carrier-protein] reductase; short chain dehydrogenase/reductase family 30C, member 1; hydroxysteroid (17-beta) dehydrogenase 8; 17-beta-hydroxysteroid dehydrogenase 8; 17-beta-HSD 8; 3-oxoacyl-[acyl-carrier-protein] reductase (EC:1.1.1.-); Protein Ke6; Ke-6; Really interesting new gene 2 protein; Testosterone 17-beta-dehydrogenase 8 (EC:1.1.1.239)
other gene names :
HSD17B8; HSD17B8; KE6; FABG; HKE6; FABGL; RING2; H2-KE6; SDR30C1; D6S2245E; dJ1033B10.9; FABGL; HKE6; RING2; 17-beta-HSD 8; Ke-6
uniprot entry name :
DHB8_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
261
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human HSD17B8
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi gi num :
14198251
ncbi acc num :
AAH08185.1
ncbi mol weight :
26,974 Da
ncbi pathways :
Metabolic Pathways (132956); Steroid Hormone Biosynthesis Pathway (82940); Steroid Hormone Biosynthesis Pathway (301)
ncbi summary :
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
uniprot summary :
HSD17B8: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Protein type: Mitochondrial; EC 1.1.1.62; EC 1.1.1.239; Lipid Metabolism - androgen and estrogen; Oxidoreductase. Chromosomal Location of Human Ortholog: 6p21.3. Cellular Component: mitochondrial envelope; mitochondrial matrix; plasma membrane. Molecular Function: estradiol 17-beta-dehydrogenase activity; protein binding; 3-hydroxyacyl-CoA dehydrogenase activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity. Biological Process: androgen metabolic process; estrogen biosynthetic process; fatty acid biosynthetic process
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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