Rabbit anti-human growth factor independent 1 transcription repressor polyclonal Antibody | MyBioSource MBS712813 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human growth factor independent 1 transcription repressor polyclonal Antibody

catalog :

MBS712813

quantity :

0.05 mL

price :

230 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS712813

products type :

Antibody

products full name :

Rabbit anti-human growth factor independent 1 transcription repressor polyclonal Antibody

products short name :

[growth factor independent 1 transcription repressor]

products name syn :

[growth factor independent 1 transcription repressor; GFI1; FLJ94509; GFI-1; ZNF163]

other names :

[Growth factor independent 1 transcription repressor; Zinc finger protein Gfi-1; zinc finger protein Gfi-1; zinc finger protein 163; growth factor independence-1; growth factor independent protein 1; growth factor independent 1 transcription repressor; Growth factor independent protein 1; Zinc finger protein 163]

other gene names :

[GFI1; GFI1; SCN2; GFI-1; GFI1A; ZNF163; ZNF163]

uniprot entry name :

GFI1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

422

purity :

Antigen Affinity Purified

form :

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

storage stability :

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB)

other info1 :

Immunogen: Human GFI1. Species: Homo sapiens (Human)

other info2 :

Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6357 / sc-8558 / sc-22796

ncbi gi num :

50959812

ncbi acc num :

AAH74866.1

ncbi pathways :

Validated Targets Of C-MYC Transcriptional Repression Pathway (169353)

ncbi summary :

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

GFI1: Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5 -TAAATCAC[AT]GCA-3 in the promoter region of a large number of genes. Component of several complexes, including the EHMT2- GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin- mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1- dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells. Defects in GFI1 are a cause of neutropenia severe congenital autosomal dominant type 2 (SCN2). SCN2 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. Defects in GFI1 are a cause of dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA). NI-CINA is a relatively mild form of neutropenia diagnosed in adults, but predisposing to leukemia in a subset of patients. Protein type: C2H2-type zinc finger protein; Transcription factor; Cell development/differentiation; Cell cycle regulation. Chromosomal Location of Human Ortholog: 1p22. Cellular Component: nuclear body; nuclear matrix; transcriptional repressor complex; nucleus. Molecular Function: protein binding; zinc ion binding. Biological Process: regulation of toll-like receptor signaling pathway; inner ear morphogenesis; cell fate commitment; viral reproduction; mechanosensory behavior; positive regulation of cell fate specification; transcription, DNA-dependent; auditory receptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell fate specification; inhibition of NF-kappaB transcription factor; negative regulation of transcription, DNA-dependent. Disease: Neutropenia, Nonimmune Chronic Idiopathic, Of Adults; Neutropenia, Severe Congenital, 2, Autosomal Dominant

size1 :

0.05 mL

price1 :

230 USD

size2 :

0.15 mL

price2 :

500

more info or order :

MyBioSource product webpage