antibody

Rabbit anti-human complement component 4 binding protein, beta polyclonal Antibody

MBS712775

0.05 mL

230 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, enzyme immunoassay

Antibody

Rabbit anti-human complement component 4 binding protein, beta polyclonal Antibody

[complement component 4 binding protein, beta]

[complement component 4 binding protein; beta; C4BPB; C4BP]

[Complement component 4 binding protein, beta; C4b-binding protein beta chain; C4b-binding protein beta chain; complement component 4 binding protein, beta]

[C4BPB; C4BPB; C4BP]

C4BPB_HUMAN

Polyclonal

IgG

Rabbit

Human

Antigen Affinity Purified

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

ELISA (EIA), Western Blot (WB)

Immunogen: Human C4BPB

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles. Species: Homo sapiens (Human). Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17215 / sc-17216

Purified Rabbit Anti human PolyClonal Antibody

13529236

AAH05378.1

Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); FOXA1 Transcription Factor Network Pathway (137979); Immune System Pathway (106386); Innate Immune System Pathway (106387); Pertussis Pathway (218111); Pertussis Pathway (218099); Regulation Of Complement Cascade Pathway (576254)

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008]

C4BPB: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: extracellular space; extracellular region; plasma membrane. Molecular Function: protein binding. Biological Process: negative regulation of complement activation, classical pathway; regulation of complement activation; positive regulation of protein catabolic process; innate immune response; blood coagulation; complement activation, classical pathway

0.05 mL

230 USD

0.15 mL

500