antibody

Rabbit anti-human mannose receptor, C type 1 polyclonal Antibody

MBS712645

0.05 mL

230 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit anti-human mannose receptor, C type 1 polyclonal Antibody

[mannose receptor, C type 1]

[mannose receptor; C type 1; MRC1; CD206; CLEC13D; MMR]

[mannose receptor, C type 1; Macrophage mannose receptor 1; macrophage mannose receptor 1; mannose receptor, C type 1-like 1; C-type lectin domain family 13 member D; macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1; CD_antigen: CD206]

[MRC1; MRC1; MMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1; CLEC13D; CLEC13DL; MRC1L1; MMR]

MRC1_HUMAN

Polyclonal

IgG

Rabbit

Human

Antigen Affinity Purified

Upon receipt, store at -20°C to -80°C. Avoid repeated freeze.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Product Type: Purified Rabbit Anti human Polyclonal Antibody. Immunogen: Human MRC1. Species: Homo sapiens (Human)

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. This protein is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region.

55665998

CAH70733.1

Q5VSJ2

Adaptive Immune System Pathway (366160); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cross-presentation Of Soluble Exogenous Antigens (endosomes) Pathway (477126); Immune System Pathway (106386); Phagosome Pathway (153910); Phagosome Pathway (153859); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Apr 2011]

MRC1: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 10p12.33. Cellular Component: cell surface; integral to plasma membrane; plasma membrane; endosome membrane. Molecular Function: mannose binding; protein binding; transmembrane receptor activity; receptor activity. Biological Process: receptor-mediated endocytosis; signal transduction

0.05 mL

230 USD

0.15 mL

500