catalog number :
MBS712464
products full name :
Rabbit anti-human caspase 3, apoptosis-related cysteine peptidase polyclonal Antibody
products short name :
caspase 3, apoptosis-related cysteine peptidase
products name syn :
caspase 3; apoptosis-related cysteine peptidase; CASP3; CPP32; CPP32B; SCA-1Caspase-3; APOPAIN; Cysteine protease CPP32; caspase3
other names :
Caspase 3, apoptosis-related cysteine peptidase; Caspase-3; caspase-3; CASP-3; CPP-32; apopain; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine protease; caspase 3, apoptosis-related cysteine peptidase; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1
other gene names :
CASP3; CASP3; CPP32; SCA-1; CPP32B; CPP32; CASP-3; CPP-32; SCA-1
uniprot entry name :
CASP3_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human CASP3
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAH16926.1
ncbi mol weight :
31,608 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!Activation Of DNA Fragmentation Factor Pathway 105683!!Activation Of Caspases Through Apoptosome-mediated Cleavage Pathway 105672!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Amyotrophic Lateral Sclerosis (ALS) Pathway 920975
ncbi summary :
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]