catalog number :
MBS712335
products full name :
Rabbit anti-human F-box and WD repeat domain containing 4 polyclonal Antibody
products short name :
F-box and WD repeat domain containing 4
other names :
F-box and WD repeat domain containing 4; F-box/WD repeat-containing protein 4; F-box/WD repeat-containing protein 4; dactylin; F-box/WD repeat protein 4; F-box and WD-40 domain protein 4; F-box and WD-40 domain-containing protein 4; F-box and WD repeat domain containing 4; Dactylin; F-box and WD-40 domain-containing protein 4
other gene names :
FBXW4; FBXW4; DAC; FBW4; FBWD4; SHFM3; SHSF3; FBW4; SHFM3
uniprot entry name :
FBXW4_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA)
other info1 :
Immunogen: Human FBXW4
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAH63415.1
ncbi mol weight :
46,337 Da
ncbi pathways :
Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway 106247!!Chaperonin-mediated Protein Folding Pathway 106242!!Metabolism Of Proteins Pathway 106230!!Protein Folding Pathway 106241
ncbi summary :
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]