catalog number :
MBS712314
products full name :
Rabbit anti-human phosphoserine aminotransferase 1 polyclonal Antibody
products short name :
phosphoserine aminotransferase 1
products name syn :
phosphoserine aminotransferase 1; PSAT1; EPIP; MGC1460; PSA; PSAT
other names :
Phosphoserine aminotransferase 1; Phosphoserine aminotransferase; phosphoserine aminotransferase; endometrial progesterone-induced protein; phosphohydroxythreonine aminotransferase; phosphoserine aminotransferase 1; Phosphohydroxythreonine aminotransferase; PSAT
other gene names :
PSAT1; PSAT1; PSA; EPIP; NLS2; PSAT; PSATD; PSA; PSAT
uniprot entry name :
SERC_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
other info1 :
Immunogen: Human PSAT1
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAH18129.1
ncbi mol weight :
35,189 Da
ncbi pathways :
Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Glycine, Serine And Threonine Metabolism Pathway (82949); Glycine, Serine And Threonine Metabolism Pathway (313); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169)
ncbi summary :
This gene encodes a member of the class-V pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is a phosphoserine aminotransferase and decreased expression may be associated with schizophrenia. Mutations in this gene are also associated with phosphoserine aminotransferase deficiency. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, and 8. [provided by RefSeq, Jul 2013]
uniprot summary :
PSAT1: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD). PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.6.1.52; Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - vitamin B6; Transferase. Chromosomal Location of Human Ortholog: 9q21.2. Cellular Component: cytoplasm; cytosol. Molecular Function: phosphoserine transaminase activity; pyridoxal phosphate binding. Biological Process: L-serine biosynthetic process; pyridoxine biosynthetic process; amino acid biosynthetic process. Disease: Phosphoserine Aminotransferase Deficiency; Neu-laxova Syndrome 2