antibody

Rabbit anti-human TATA box binding protein polyclonal Antibody

MBS712233

0.05 mL

375 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, enzyme immunoassay

Antibody

Rabbit anti-human TATA box binding protein polyclonal Antibody

TATA box binding protein

TATA box binding protein; TBP; GTF2D; GTF2D1; MGC117320; MGC126054; MGC126055; SCA17; TFIID

TATA box binding protein; TATA-box-binding protein; TATA-box-binding protein; TATA-box factor; TATA sequence-binding protein; TATA-box binding protein N-terminal domain; transcription initiation factor TFIID TBP subunit; TATA box binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box factor; Transcription initiation factor TFIID TBP subunit

TBP; TBP; HDL4; GTF2D; SCA17; TFIID; GTF2D1; GTF2D1; TF2D; TFIID

TBP_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

338

Antigen Affinity Purified

ELISA (EIA), Western Blot (WB)

Immunogen: Human TBP

Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

82571689

AAI10342.1

35,657 Da

Basal Transcription Factors Pathway (83038); Basal Transcription Factors Pathway (443); Disease Pathway (530764); Epigenetic Regulation Of Gene Expression Pathway (980449); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Eukaryotic Transcription Initiation Pathway (198917); Gene Expression Pathway (105937); Glucocorticoid Receptor Regulatory Network Pathway (138014); HIV Infection Pathway (105983)

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]

TBP: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Binds DNA as monomer. Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B TAF1C and TAF1D. Association of TBP to form either TFIID or SL1/TIF-IB appears to be mutually exclusive. Interacts with TAF1A, TAF1B and TAF1C. Interacts with TFIIB, NCOA6, DRAP1, DR1 and ELF3. Interacts with SPIB, SNAPC1, SNAPC2 and SNAPC4. Interacts with UTF1. Interacts with BRF2. Interacts with UBTF. Interacts with GPBP1. Interacts with CITED2. Interacts with ATF7IP. Interacts with HIV-1 Tat. Widely expressed, with levels highest in the testis and ovary. Belongs to the TBP family. Protein type: Nuclear receptor co-regulator; DNA-binding; Transcription initiation complex. Chromosomal Location of Human Ortholog: 6q27. Cellular Component: nucleoplasm; transcription factor TFIID complex; male pronucleus; cytoplasm; female pronucleus; transcription factor TFIIA complex. Molecular Function: protein binding; transcription factor activity; transcription factor binding. Biological Process: transcription from RNA polymerase II promoter; chromatin silencing at rDNA; transcription initiation from RNA polymerase II promoter; viral reproduction; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase I promoter; RNA elongation from RNA polymerase I promoter; termination of RNA polymerase I transcription; regulation of gene expression, epigenetic; transcription from RNA polymerase III promoter; negative regulation of gene expression, epigenetic; RNA elongation from RNA polymerase II promoter; gene expression; spermatogenesis; transcription initiation from RNA polymerase I promoter. Disease: Parkinson Disease, Late-onset; Spinocerebellar Ataxia 17

0.05 mL

375 USD

0.15 mL

715