catalog number :
MBS712223
products full name :
Rabbit anti-human phospholipase A2, group XIIA polyclonal Antibody
products short name :
[phospholipase A2, group XIIA]
products name syn :
[phospholipase A2; group XIIA; PLA2G12A; GXII; PLA2G12; ROSSY]
other names :
[Phospholipase A2, group XIIA; Group XIIA secretory phospholipase A2; group XIIA secretory phospholipase A2; sPLA2-XII; GXII sPLA2; phospholipase A2, group XII; group XII secreted phospholipase A2; group XIIA secreted phospholipase A2; phosphatidylcholine 2-acylhydrolase 12A; phospholipase A2, group XIIA; Phosphatidylcholine 2-acylhydrolase 12A]
other gene names :
[PLA2G12A; PLA2G12A; GXII; ROSSY; PLA2G12; PLA2G12; GXII sPLA2; sPLA2-XII]
uniprot entry name :
PG12A_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
storage stability :
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human PLA2G12A. Species: Homo sapiens (Human). Research Area: Others. Product Type: Purified Rabbit Anti human PolyClonal Antibody
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-104300 / sc-104302
ncbi acc num :
AAH17218.1
ncbi pathways :
Acyl Chain Remodelling Of PC Pathway (645321); Acyl Chain Remodelling Of PE Pathway (645317); Acyl Chain Remodelling Of PG Pathway (645328); Acyl Chain Remodelling Of PI Pathway (645326); Acyl Chain Remodelling Of PS Pathway (645324); Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (366); Ether Lipid Metabolism Pathway (82990); Ether Lipid Metabolism Pathway (365); Fat Digestion And Absorption Pathway (194385)
ncbi summary :
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
uniprot summary :
PLA2G12A: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine. Belongs to the phospholipase A2 family. Protein type: Lipid Metabolism - linoleic acid; Phospholipase; Endoplasmic reticulum; Secreted; Secreted, signal peptide; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - alpha-linolenic acid; EC 3.1.1.4; Lipid Metabolism - arachidonic acid. Chromosomal Location of Human Ortholog: 4q25. Cellular Component: Golgi apparatus; endoplasmic reticulum; extracellular region. Molecular Function: calcium-dependent phospholipase A2 activity; calcium ion binding. Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process