antibody

Rabbit anti-human NLR family, pyrin domain containing 3 polyclonal Antibody

MBS711672

0.05 ml

375 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

Rabbit anti-human NLR family, pyrin domain containing 3 polyclonal Antibody

NLR family, pyrin domain containing 3

NLR family; pyrin domain containing 3; NLRP3; AGTAVPRL; AII; AII/AVP; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCU; FLJ95925; MWS; NALP3; PYPAF1

NLR family, pyrin domain containing 3; NACHT, LRR and PYD domains-containing protein 3; NACHT, LRR and PYD domains-containing protein 3; cryopyrin; caterpiller protein 1.1; PYRIN-containing APAF1-like protein 1; NACHT, LRR and PYD containing protein 3; cold autoinflammatory syndrome 1 protein; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; NLR family, pyrin domain containing 3; Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1

NLRP3; NLRP3; AII; AVP; FCU; MWS; FCAS; CIAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL; C1orf7; CIAS1; NALP3; PYPAF1; CLR1.1

NALP3_HUMAN

Polyclonal

IgG

Rabbit

Human

1036

Antigen Affinity Purified

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

Immunogen: Human NALP3

Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

219518791

AAI43363.1

115,968 Da

Immune System Pathway 106386!!Inflammasomes Pathway 366166!!Influenza A Pathway 217173!!Influenza A Pathway 217150!!Innate Immune System Pathway 106387!!NOD Pathway 198792!!NOD-like Receptor Signaling Pathway 122191!!NOD-like Receptor Signaling Pathway 122131!!Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways 366164!!Pertussis Pathway 218111

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]

0.05 ml

375 USD