antibody

Rabbit anti-human integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) polyclonal Antibody

MBS711655

0.05 mL

375 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunocytochemistry, immunoprecipitation, enzyme immunoassay

Antibody

Rabbit anti-human integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) polyclonal Antibody

integrin, alpha 3

integrin; alpha 3 (antigen CD49C; alpha 3 subunit of VLA-3 receptor); ITGA3; CD49C; FLJ34631; FLJ34704; GAP-B3; GAPB3; MSK18; VCA-2; VL3A; VLA3a

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor), isoform CRA_b; Integrin alpha-3; integrin alpha-3; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C; antigen identified by monoclonal antibody J143; very late activation protein 3 receptor, alpha-3 subunit; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD_antigen: CD49cCleaved into the following 2 chains:Integrin alpha-3 heavy chain; Integrin alpha-3 light chain

ITGA3; ITGA3; VL3A; CD49C; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3; MSK18; GAPB3

ITA3_HUMAN

Polyclonal

IgG

Rabbit

Human; Other species are not tested. Please decide the specificity by homology.

1066

Antigen Affinity Purified

Liquid

Shipped at 4 degree C Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

ELISA:Use at an assay dependent dilution. WB : 1:200-1:2000. IP : 1:200-1:2000. IF : 1:20-1:200(Recommender dilutions). Positive WB detected in:PC-3 cells, A549 cells, human brain tissue, human heart tissue,human testis tissue. Positive IP detected in: PC-3 cells. Positive IF detected in: A549 cells

Immunogen: Human ITGA3. Conjugate: Non-conjugated

Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondinand CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

119615053

EAW94647.1

Arf6 Trafficking Events Pathway (137954); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Basigin Interactions Pathway (106065); CXCR4-mediated Signaling Events Pathway (137910); Cell Surface Interactions At The Vascular Wall Pathway (106062); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); ECM-receptor Interaction Pathway (83068)

The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

ITGA3: an integral membrane protein that heterodimerizes with a beta chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. Undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1. Two alternatively spliced isoforms have been described. Protein type: Cell adhesion; Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 17q21.33. Cellular Component: filopodium membrane; cell surface; growth cone; focal adhesion; perinuclear region of cytoplasm; basolateral plasma membrane; plasma membrane; excitatory synapse; integrin complex; receptor complex; external side of plasma membrane. Molecular Function: integrin binding; collagen binding; protein domain specific binding; protein binding; protease binding; protein heterodimerization activity; fibronectin binding; metal ion binding; laminin binding; glycoprotein binding. Biological Process: response to drug; skin development; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; maternal process involved in pregnancy; cell-matrix adhesion; heart development; regulation of BMP signaling pathway; regulation of Wnt receptor signaling pathway; neuron migration; mesodermal cell differentiation; memory; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of Rho protein signal transduction; blood coagulation; leukocyte migration; negative regulation of cell projection organization and biogenesis; lung development. Disease: Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital

0.05 mL

375 USD

0.15 mL

715