catalog number :
MBS711639
products full name :
Rabbit anti-human adhesion regulating molecule 1 polyclonal Antibody
products short name :
adhesion regulating molecule 1
products name syn :
adhesion regulating molecule 1; ADRM1; ARM1; GP110; MGC29536; Rpn13
other names :
Adhesion regulating molecule 1; Proteasomal ubiquitin receptor ADRM1; proteasomal ubiquitin receptor ADRM1; rpn13 homolog; M(r) 110,000 surface antigen; 110 kDa cell membrane glycoprotein; proteasome regulatory particle non-ATPase 13; adhesion regulating molecule 1; 110 kDa cell membrane glycoprotein; Gp110; Adhesion-regulating molecule 1; ARM-1; Proteasome regulatory particle non-ATPase 13; hRpn13; Rpn13 homolog
other gene names :
ADRM1; ADRM1; ARM1; ARM-1; GP110; GP110; Gp110; ARM-1; hRpn13
uniprot entry name :
ADRM1_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
other info1 :
Immunogen: Human ADRM1
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAH17245.1
ncbi mol weight :
42,153 Da
ncbi summary :
This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
uniprot summary :
ADRM1: Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity. Interacts with PSMD1, ubiquitin and UCHL5. Belongs to the ADRM1 family. Protein type: Proteasome complex; Cell development/differentiation. Chromosomal Location of Human Ortholog: 20q13.33. Cellular Component: nucleoplasm; proteasome complex; membrane; integral to plasma membrane; cytoplasm; plasma membrane. Molecular Function: protein binding; protease binding. Biological Process: RNA elongation from RNA polymerase II promoter; proteasome assembly