product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human ATG4 autophagy related 4 homolog B (S. cerevisiae) polyclonal Antibody
catalog :
MBS711449
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
product information
catalog number :
MBS711449
products type :
Antibody
products full name :
Rabbit anti-human ATG4 autophagy related 4 homolog B (S. cerevisiae) polyclonal Antibody
products short name :
ATG4 autophagy related 4 homolog B
products name syn :
ATG4 autophagy related 4 homolog B (S. cerevisiae); ATG4B; APG4B; AUTL1; MGC1353
other names :
ATG4 autophagy related 4 homolog B (S. cerevisiae), isoform CRA_b; Cysteine protease ATG4B; cysteine protease ATG4B; hAPG4B; autophagin-1; APG4 autophagy 4 homolog B; AUT-like 1 cysteine endopeptidase; ATG4 autophagy related 4 homolog B; autophagy-related protein 4 homolog B; autophagy-related cysteine endopeptidase 1; autophagy related 4B, cysteine peptidase; AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B
other gene names :
ATG4B; ATG4B; APG4B; AUTL1; APG4B; AUTL1; KIAA0943; hAPG4B
uniprot entry name :
ATG4B_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
331
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human ATG4B
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi gi num :
119591685
ncbi acc num :
EAW71279.1
ncbi mol weight :
42,622 Da
ncbi pathways :
Regulation Of Autophagy Pathway (83058); Regulation Of Autophagy Pathway (468)
ncbi summary :
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
uniprot summary :
ATG4B: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; EC 3.4.22.-; Autophagy; Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 2q37.3. Cellular Component: cytoplasm; cytosol. Molecular Function: protein binding; cysteine-type endopeptidase activity; endopeptidase activity; cysteine-type peptidase activity. Biological Process: protein delipidation; positive regulation of protein catabolic process; mitochondrion degradation; autophagy; protein processing; C-terminal protein lipidation; proteolysis; protein targeting to membrane; positive regulation of autophagy; cellular response to nitrogen starvation; autophagic vacuole formation
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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