catalog number :
MBS711440
products full name :
Rabbit anti-human HtrA serine peptidase 4 polyclonal Antibody
products short name :
HtrA serine peptidase 4
products name syn :
HtrA serine peptidase 4; HTRA4; FLJ90724
other names :
HtrA serine peptidase 4; Serine protease HTRA4; serine protease HTRA4; probable serine protease HTRA4; high-temperature requirement factor A4; HtrA serine peptidase 4; High-temperature requirement factor A4
other gene names :
HTRA4; HTRA4
uniprot entry name :
HTRA4_HUMAN
reactivity :
Human, Mouse,Rat; Other species are not tested. Please decide the specificity by homology.
purity :
Antigen Affinity Purified
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
ELISA: Use at an assay dependent dilution. WB: 1:200-1:2000 (Recommender dilutions) . Positive WB detected in : Human placenta tissue
other info1 :
Immunogen: Human HTRA4. Conjugate : Non-conjugated
other info2 :
Storage Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
ncbi acc num :
AAH57765.1
ncbi mol weight :
50,979 Da
ncbi summary :
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
uniprot summary :
HTRA4: Serine protease (Probable). Belongs to the peptidase S1B family. Protein type: Protease; Secreted, signal peptide; Secreted; EC 3.4.21.-. Chromosomal Location of Human Ortholog: 8p11.22. Cellular Component: extracellular region. Molecular Function: insulin-like growth factor binding; serine-type endopeptidase activity; endopeptidase activity. Biological Process: regulation of cell growth; proteolysis; negative regulation of transforming growth factor beta receptor signaling pathway