product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human salvador homolog 1 (Drosophila) polyclonal Antibody
catalog :
MBS711404
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS711404
products type :
Antibody
products full name :
Rabbit anti-human salvador homolog 1 (Drosophila) polyclonal Antibody
products short name :
salvador homolog 1
products name syn :
salvador homolog 1 (Drosophila); SAV1; SAV; WW45; WWP4
other names :
Salvador homolog 1 (Drosophila); Protein salvador homolog 1; protein salvador homolog 1; hWW45; 1700040G09Rik; 45 kDa WW domain protein; WW domain-containing adaptor 45; salvador family WW domain containing protein 1; 45 kDa WW domain protein; hWW45
other gene names :
SAV1; SAV1; SAV; WW45; WWP4; WW45; hWW45
uniprot entry name :
SAV1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
383
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human SAV1
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi gi num :
18088228
ncbi acc num :
AAH20537.1
ncbi mol weight :
44,634 Da
ncbi pathways :
Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Signal Transduction Pathway (477114); Signaling By Hippo Pathway (576275)
ncbi summary :
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]
uniprot summary :
SAV1: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Homodimer. Stabilized through interaction with STK3/MST2 or STK4/MST1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in the presence of STK3/MST2. Interacts with WTIP and AJUBA. Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 14q13-q23. Cellular Component: cytoplasm; nucleus; cytosol. Molecular Function: protein binding. Biological Process: keratinocyte differentiation; hair follicle development; negative regulation of cardiac muscle cell proliferation; positive regulation of apoptosis; negative regulation of epithelial cell proliferation
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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