catalog number :
MBS711209
products full name :
Rabbit anti-human emopamil binding protein (sterol isomerase) polyclonal Antibody
products short name :
emopamil binding protein
products name syn :
emopamil binding protein (sterol isomerase); EBP; CDPX2; CHO2; CPX; CPXD
other names :
emopamil binding protein, partial; 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; sterol 8-isomerase; D8-D7 sterol isomerase; cholestenol Delta-isomerase; delta(8)-Delta(7) sterol isomerase; emopamil-binding protein (sterol isomerase); 3-beta-hydroxysteroid-delta-8,delta-7-isomerase; Chondrodysplasia punctata-2, X-linked dominant (Happle syndrome); emopamil binding protein (sterol isomerase); Cholestenol Delta-isomerase; Delta(8)-Delta(7) sterol isomerase; D8-D7 sterol isomerase; Emopamil-binding protein
other gene names :
EBP; EBP; CPX; CHO2; CPXD; CDPX2; D8-D7 sterol isomerase
uniprot entry name :
EBP_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human EBP
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AIL31429.1
ncbi mol weight :
26,353 Da
ncbi pathways :
Cholesterol Biosynthesis Pathway 106142!!Cholesterol Biosynthesis, Squalene 2,3-epoxide = Cholesterol Pathway 413390!!Cholesterol Biosynthesis, Squalene 2,3-epoxide = Cholesterol Pathway 468282!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Steroid Biosynthesis Pathway 82937!!Steroid Biosynthesis Pathway 298!!Cholesterol Biosynthesis I Pathway 142267!!Cholesterol Biosynthesis I Pathway 138627
ncbi summary :
The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues ( 23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008]