catalog number :
MBS711096
products full name :
Rabbit anti-human CCR4-NOT transcription complex, subunit 1 polyclonal Antibody
products short name :
CCR4-NOT transcription complex, subunit 1
products name syn :
CCR4-NOT transcription complex; subunit 1; CNOT1; AD-005; CDC39; DKFZp686E0722; DKFZp686O168; FLJ36492; FLJ90644; KIAA1007; NOT1; NOT1H
other names :
CCR4-NOT transcription complex subunit 1 isoform a; CCR4-NOT transcription complex subunit 1; CCR4-NOT transcription complex subunit 1; CCR4-associated factor 1; adrenal gland protein AD-005; negative regulator of transcription subunit 1 homolog; NOT1 (negative regulator of transcription 1, yeast) homolog; CCR4-NOT transcription complex, subunit 1; CCR4-associated factor 1; Negative regulator of transcription subunit 1 homolog; NOT1H; hNOT1
other gene names :
CNOT1; CNOT1; NOT1; CDC39; NOT1H; AD-005; CDC39; KIAA1007; NOT1; NOT1H; hNOT1
uniprot entry name :
CNOT1_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB)
other info1 :
Immunogen: Human CNOT1
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
NP_057368.3
ncbi gb acc num :
NM_016284.4
ncbi mol weight :
173,792 Da
ncbi pathways :
Deadenylation Of MRNA Pathway (160994); Deadenylation-dependent MRNA Decay Pathway (160993); Gene Expression Pathway (105937); RNA Degradation Pathway (117291); RNA Degradation Pathway (116127)
uniprot summary :
NOT1: represses ligand-dependent transcriptional activation by oestrogen receptor (ER) alpha and several RXR heterodimers. Interacts with the ligand-binding domain of estrogen receptor-alpha in a hormone-dependent fashion. Protein type: Transcription, coactivator/corepressor; RNA-binding; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 16q21. Cellular Component: nucleoplasm; peroxisomal membrane; extracellular space; membrane; cytosol; CCR4-NOT complex. Molecular Function: protein domain specific binding; protein binding; poly(A)-specific ribonuclease activity; retinoic acid receptor binding; estrogen receptor binding; protein complex scaffold. Biological Process: poly(A) tail shortening; negative regulation of retinoic acid receptor signaling pathway; transcription, DNA-dependent; negative regulation of translation; multicellular organismal development; gene expression; negative regulation of transcription from RNA polymerase II promoter; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay; negative regulation of estrogen receptor signaling pathway