product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human glycine amidinotransferase (L-arginine:glycine amidinotransferase) polyclonal Antibody
catalog :
MBS710988
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS710988
products type :
Antibody
products full name :
Rabbit anti-human glycine amidinotransferase (L-arginine:glycine amidinotransferase) polyclonal Antibody
products short name :
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
products name syn :
glycine amidinotransferase (L-arginine:glycine amidinotransferase); GATM; AGAT; AT
other names :
glycine amidinotransferase, mitochondrial; Glycine amidinotransferase, mitochondrial; glycine amidinotransferase, mitochondrial; transamidinase; glycine amidinotransferase (L-arginine:glycine amidinotransferase); L-arginine:glycine amidinotransferase; Transamidinase
other gene names :
GATM; GATM; AT; AGAT; CCDS3; AGAT
uniprot entry name :
GATM_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human,Mouse,Rat; Other species are not tested. Please decide the specificity by homology.
sequence length :
423
purity :
Antigen Affinity Purified
form :
Liquid
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ELISA: Use at an assay dependent dilution. WB : 1:500-1:5000 . IHC : 1:20-1:200 (Recommender dilutions)!!Positive WB detected in Mouse kidney tissue, human kidney tissue, rat kidney tissue !!Positive IHC detected in Human pancreas cancer tissue
other info1 :
Immunogen: Human GATM. Conjugate: Non-conjugated
other info2 :
Storage Buffer: PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
products description :
Rabbit polyclonal to GATM . Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
ncbi gi num :
4503933
ncbi acc num :
NP_001473.1
ncbi gb acc num :
NM_001482.2
ncbi pathways :
Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Creatine Metabolism Pathway (106192); Creatine Pathway (413359); Creatine Pathway (468234); Glycine, Serine And Threonine Metabolism Pathway (82949); Glycine, Serine And Threonine Metabolism Pathway (313); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169)
ncbi summary :
This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders. [provided by RefSeq, Jul 2008]
uniprot summary :
GATM: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis. Defects in GATM are the cause of arginine:glycine amidinotransferase deficiency (AGAT deficiency). AGAT deficiency is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of expressive and cognitive speech, and severe depletion of creatine/phosphocreatine in the brain. Belongs to the amidinotransferase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.4.1; Transferase; Mitochondrial. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: mitochondrial inner membrane; mitochondrial intermembrane space. Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines; glycine amidinotransferase activity. Biological Process: response to mercury ion; response to peptide hormone stimulus; creatine biosynthetic process; tissue regeneration; response to oxidative stress; creatine metabolic process; response to nutrient. Disease: Cerebral Creatine Deficiency Syndrome 3
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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