Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody | MyBioSource MBS710952 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody

catalog :

MBS710952

quantity :

0.05 mL

price :

230 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

image

image 1 :

Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody . IgG. Non-conjugated . Antigen Affinity Purified . Positive WB detected in : Human brain tissue, human liver tissue . Positive IHC detected in :human lung cancer . human brain tissue were subjected to SDS PAGE followed by western blot with PRCP antibody at dilution of 1:400

image 2 :

Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody . IgG. Non-conjugated . Antigen Affinity Purified . Positive WB detected in : Human brain tissue, human liver tissue . Positive IHC detected in :human lung cancer . human liver tissue were subjected to SDS PAGE followed by western blot with PRCP antibody at dilution of 1:400

image 3 :

Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody . IgG. Non-conjugated . Antigen Affinity Purified . Positive WB detected in : Human brain tissue, human liver tissue . Positive IHC detected in :human lung cancer . Immunohistochemical of paraffin-embedded human lung cancer using PRCP antibody at dilution of 1:50 (under 10x lens)

product information

catalog number :

MBS710952

products type :

Antibody

products full name :

Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody

products short name :

[prolylcarboxypeptidase]

products name syn :

[prolylcarboxypeptidase (angiotensinase C); PRCP; HUMPCP; MGC2202; PCP]

other names :

[prolylcarboxypeptidase; Lysosomal Pro-X carboxypeptidase; lysosomal Pro-X carboxypeptidase; angiotensinase C; proline carboxypeptidase; lysosomal carboxypeptidase C; prolylcarboxypeptidase isoform 1 preproprotein; prolylcarboxypeptidase (angiotensinase C); Angiotensinase C; Lysosomal carboxypeptidase C; Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP]

other gene names :

[PRCP; PRCP; PCP; HUMPCP; PCP; PRCP]

uniprot entry name :

PCP_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

496

purity :

Antigen Affinity Purified

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

image1 heading :

SDS-PAGE

image2 heading :

SDS-PAGE

image3 heading :

Immunohistochemical of paraffin

image4 heading :

Immunohistochemical of paraffin

image4 description :

Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody . IgG. Non-conjugated . Antigen Affinity Purified . Positive WB detected in : Human brain tissue, human liver tissue . Positive IHC detected in :human lung cancer . Immunohistochemical of paraffin-embedded human lung cancer using PRCP antibody at dilution of 1:50 (under 40x lens)

other info1 :

Immunogen: Human PRCP

other info2 :

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49272 / sc-49274

ncbi gi num :

431321

ncbi acc num :

AAA99891.1

ncbi mol weight :

58,100 Da

ncbi pathways :

Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); Hemostasis Pathway (106028); Intrinsic Pathway (106059); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868)

ncbi summary :

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

uniprot summary :

PRCP: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. Belongs to the peptidase S28 family. Protein type: EC 3.4.16.2; Protease. Chromosomal Location of Human Ortholog: 11q14. Cellular Component: lysosome; plasma membrane. Molecular Function: serine carboxypeptidase activity; protein binding. Biological Process: negative regulation of systemic arterial blood pressure; plasma kallikrein-kinin cascade; glucose homeostasis; blood coagulation; proteolysis; regulation of blood vessel endothelial cell migration; angiogenesis involved in wound healing; blood coagulation, intrinsic pathway

size1 :

0.05 mL

price1 :

230 USD

size2 :

0.15 mL

price2 :

500

more info or order :

MyBioSource product webpage