catalog number :
MBS710923
products full name :
Rabbit anti-human S-adenosylhomocysteine hydrolase-like 1 polyclonal Antibody
products short name :
S-adenosylhomocysteine hydrolase-like 1
products name syn :
S-adenosylhomocysteine hydrolase-like 1; AHCYL1; DCAL; IRBIT; PRO0233; XPVKONA
other names :
S-adenosylhomocysteine hydrolase-like 1; Putative adenosylhomocysteinase 2; putative adenosylhomocysteinase 2; adoHcyase 2; DC-expressed AHCY-like molecule; S-adenosyl-L-homocysteine hydrolase 2; S-adenosyl homocysteine hydrolase homolog; dendritic cell expressed AHCY-like protein; protein phosphatase 1, regulatory subunit 78; S-adenosylhomocysteine hydrolase-like protein 1; inositol 1,4,5-trisphosphate receptor-binding protein; adenosylhomocysteinase-like 1; DC-expressed AHCY-like molecule; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like protein 1
other gene names :
AHCYL1; AHCYL1; DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA; DCAL; XPVKONA; AdoHcyase 2
uniprot entry name :
SAHH2_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB)
other info1 :
Immunogen: Human AHCYL1
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
CAH70966.1
ncbi mol weight :
53,753 Da
ncbi pathways :
Cysteine And Methionine Metabolism Pathway (104488); Cysteine And Methionine Metabolism Pathway (103421); Metabolic Pathways (132956); Methionine Degradation Pathway (413353); Methionine Degradation Pathway (468228); Trans-sulfuration And One Carbon Metabolism Pathway (920958); Cysteine Biosynthesis III (mammalia) Pathway (545271); Methionine Degradation I (to Homocysteine) Pathway (142372); Superpathway Of Methionine Degradation (142373)
ncbi summary :
The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
uniprot summary :
AHCYL1: an inositol 1,4,5-trisphosphate receptor 1 (IP3R1)-binding protein that inhibits IP3 binding to IP3R1 and IP3-induced intracellular Ca2 release. Suppresses the activation of IP3R1 via a phosphorylation-dependent mechanism. Also binds the Na/HCO3 cotransporter 1 (SLC4A4) and may play an important role in pH regulation. Contains a domain homologous to S-adenosylhomocysteine hydrolase (SAHH), although it is reported to possess no hydrolase activity. Its expression is induced in cultured monocytes when they are differentiated into dendritic cells (DC) by exposure to GM-CSF and IL-4. Protein type: Amino Acid Metabolism - cysteine and methionine; Hydrolase; EC 3.3.1.1; Other Amino Acids Metabolism - selenoamino acid. Chromosomal Location of Human Ortholog: 1p13.2. Cellular Component: endoplasmic reticulum; cytosol. Molecular Function: protein binding; adenosylhomocysteinase activity. Biological Process: S-adenosylmethionine cycle; regulation of ion transmembrane transporter activity; mRNA polyadenylation; one-carbon compound metabolic process; protein export from nucleus; regulation of mRNA 3 -end processing