Rabbit anti-human aldehyde dehydrogenase 7 family, member A1 polyclonal Antibody | MyBioSource MBS710903 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human aldehyde dehydrogenase 7 family, member A1 polyclonal Antibody

catalog :

MBS710903

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS710903

products type :

Antibody

products full name :

Rabbit anti-human aldehyde dehydrogenase 7 family, member A1 polyclonal Antibody

products short name :

aldehyde dehydrogenase 7 family, member A1

products name syn :

aldehyde dehydrogenase 7 family; member A1; ALDH7A1; ATQ1; EPD; FLJ11738; FLJ92814; PDE

other names :

Aldehyde dehydrogenase 7 family, member A1; Alpha-aminoadipic semialdehyde dehydrogenase; alpha-aminoadipic semialdehyde dehydrogenase; antiquitin-1; P6c dehydrogenase; alpha-AASA dehydrogenase; 26g turgor protein homolog; betaine aldehyde dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenase; aldehyde dehydrogenase 7 family, member A1; Aldehyde dehydrogenase family 7 member A1 (EC:1.2.1.3); Antiquitin-1; Betaine aldehyde dehydrogenase (EC:1.2.1.8); Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase

other gene names :

ALDH7A1; ALDH7A1; EPD; PDE; ATQ1; ATQ1; Alpha-AASA dehydrogenase; P6c dehydrogenase

uniprot entry name :

AL7A1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

511

purity :

Antigen Affinity Purified

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

other info1 :

Immunogen: Human ALDH7A1

other info2 :

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

ncbi gi num :

127796373

ncbi acc num :

AAH02515.3

ncbi mol weight :

53,987 Da

ncbi pathways :

Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Ascorbate And Aldarate Metabolism Pathway (82932); Ascorbate And Aldarate Metabolism Pathway (293); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Fatty Acid Degradation Pathway (82935); Fatty Acid Degradation Pathway (296); GABA Biosynthesis, Eukaryotes, Putrescine = GABA Pathway (413399); GABA Biosynthesis, Eukaryotes, Putrescine = GABA Pathway (468314)

ncbi summary :

The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. [provided by RefSeq, Jan 2011]

uniprot summary :

ALDH7A1: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. Defects in ALDH7A1 are the cause of pyridoxine-dependent epilepsy (PDE). PDE is characterized by a combination of various seizure types. It usually occurs in the first hours of life and is unresponsive to standard anticonvulsants, responding only to immediate administration of pyridoxine hydrochloride. Belongs to the aldehyde dehydrogenase family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.2.1.8; Lipid Metabolism - glycerolipid; Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Mitochondrial; EC 1.2.1.3; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - histidine; Secondary Metabolites Metabolism - limonene and pinene degradation; Carbohydrate Metabolism - ascorbate and aldarate; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - arginine and proline; Oxidoreductase; EC 1.2.1.31; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - tryptophan. Chromosomal Location of Human Ortholog: 5q31. Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; nucleus; cytosol. Molecular Function: L-aminoadipate-semialdehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; protein binding; betaine-aldehyde dehydrogenase activity. Biological Process: sensory perception of sound; glycine betaine biosynthetic process from choline; lysine catabolic process; aldehyde metabolic process. Disease: Epilepsy, Pyridoxine-dependent

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage