antibody

Rabbit anti-human eukaryotic translation initiation factor 2-alpha kinase 1 polyclonal Antibody

MBS710872

0.05 mL

230 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

Rabbit anti-human eukaryotic translation initiation factor 2-alpha kinase 1 polyclonal Antibody

[eukaryotic translation initiation factor 2-alpha kinase 1]

[eukaryotic translation initiation factor 2-alpha kinase 1; EIF2AK1; HCR; HRI; KIAA1369]

[Eukaryotic translation initiation factor 2-alpha kinase 1; Eukaryotic translation initiation factor 2-alpha kinase 1; eukaryotic translation initiation factor 2-alpha kinase 1; heme-regulated inhibitor; heme-regulated repressor; heme-controlled repressor; heme sensitive initiation factor 2a kinase; heme regulated initiation factor 2 alpha kinase; heme-regulated initiation factor 2-alpha kinase; hemin-sensitive initiation factor 2-alpha kinase; heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; eukaryotic translation initiation factor 2-alpha kinase 1; Heme-controlled repressor; HCR; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; Heme-regulated inhibitor; Hemin-sensitive initiation factor 2-alpha kinase]

[EIF2AK1; EIF2AK1; HCR; HRI; HRI; KIAA1369; HCR]

E2AK1_HUMAN

polyclonal

IgG

rabbit

Human, Mouse, Rat

Antigen Affinity Purified

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

Immunogen: Human EIF2AK1. Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Product Type: Purified Rabbit Anti human PolyClonal Antibody. Species: Homo sapiens (Human)

32172458

Q9BQI3.2

Q9BQI3

Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865); Influenza A Pathway (217173); Influenza A Pathway (217150); Measles Pathway (213306); Measles Pathway (213277)

The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

HRI: a protein kinase of the PEK family. Phosphorylates the alpha subunit of eukaryotic initiation factor 2 in response to various stress conditions, inhibiting protein synthesis at the level of initiation. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme. Binding of nitric oxide (NO) to the heme iron in the N-terminal heme-binding domain activates the kinase activity, while binding of carbon monoxide (CO) suppresses kinase activity. Requires association with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosporylation. Two alternatively spliced isoforms have been described. Protein type: Translation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Other group; PEK family. Chromosomal Location of Human Ortholog: 7p22. Cellular Component: cytoplasm. Molecular Function: protein homodimerization activity; heme binding; ATP binding; eukaryotic translation initiation factor 2alpha kinase activity. Biological Process: response to external stimulus; negative regulation of cell proliferation; negative regulation of translational initiation by iron; protoporphyrinogen IX metabolic process; protein amino acid autophosphorylation; response to stress; negative regulation of hemoglobin biosynthetic process

0.05 mL

230 USD

0.15 mL

500