product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human heat shock factor binding protein 1 polyclonal Antibody
catalog :
MBS710716
quantity :
0.05 mL
price :
230 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS710716
products type :
Antibody
products full name :
Rabbit anti-human heat shock factor binding protein 1 polyclonal Antibody
products short name :
[heat shock factor binding protein 1]
products name syn :
[heat shock factor binding protein 1; HSBP1; DKFZp686D1664; DKFZp686O24200; NPC-A-13]
other names :
[heat shock factor binding protein 1; Heat shock factor-binding protein 1; heat shock factor-binding protein 1; nasopharyngeal carcinoma-associated antigen 13; heat shock factor binding protein 1; Nasopharyngeal carcinoma-associated antigen 13; NPC-A-13]
other gene names :
[HSBP1; HSBP1; NPC-A-13; HSF1BP; NPC-A-13]
uniprot entry name :
HSBP1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
76
purity :
Antigen Affinity Purified
storage stability :
Upon receipt, store at -20°c or -80°C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Product Type: Purified Rabbit Anti human PolyClonal Antibody. Immunogen: Human HSBP1. Species: Homo sapiens (Human)
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles. Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-54611
ncbi gi num :
119615920
ncbi acc num :
EAW95514.1
ncbi pathways :
Attenuation Phase Pathway (980473); Cellular Response To Heat Stress Pathway (980470); Cellular Responses To Stress Pathway (645258); HSF1 Activation Pathway (980471); HSF1-dependent Transactivation Pathway (980472)
ncbi summary :
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
uniprot summary :
HSBP1: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process. Belongs to the HSBP1 family. Chromosomal Location of Human Ortholog: 16q23.3. Cellular Component: nucleoplasm; cytoskeleton; nucleus. Molecular Function: transcription corepressor activity. Biological Process: muscle contraction; negative regulation of transcription from RNA polymerase II promoter
size1 :
0.05 mL
price1 :
230 USD
size2 :
0.15 mL
price2 :
500
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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