product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human squamous cell carcinoma antigen recognized by T cells 3 polyclonal Antibody
catalog :
MBS710643
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS710643
products type :
Antibody
products full name :
Rabbit anti-human squamous cell carcinoma antigen recognized by T cells 3 polyclonal Antibody
products short name :
squamous cell carcinoma antigen recognized by T cells 3
products name syn :
squamous cell carcinoma antigen recognized by T cells 3; SART3; DSAP1; KIAA0156; MGC138188; P100; RP11-13G14; TIP110; p110; p110(nrb)
other names :
squamous cell carcinoma antigen recognized by T-cells 3; Squamous cell carcinoma antigen recognized by T-cells 3; squamous cell carcinoma antigen recognized by T-cells 3; SART-3; hSART-3; tat-interacting protein of 110 kDa; squamous cell carcinoma antigen recognized by T cells 3; Tat-interacting protein of 110 kDa; Tip110
other gene names :
SART3; SART3; P100; p110; DSAP1; TIP110; p110(nrb); RP11-13G14; KIAA0156; TIP110; SART-3; hSART-3; Tip110
uniprot entry name :
SART3_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human ,Mouse, rat ;Other species are not tested. Please decide the specificity by homology.
sequence length :
963
purity :
Antigen affinity purification
form :
Liquid
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ELISA: Use at an assay dependent dilution. WB: 1:500-1:5000 . IHC: 1:50-1:200 (Recommender dilutions) . Positive WB detected in: HeLa cells, Jurkat cells . Positive IHC detected in: Human testis
other info1 :
Immunogen: Human SART3. Conjugate: Non-conjugated
other info2 :
Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
products description :
Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.
ncbi gi num :
7661952
ncbi acc num :
NP_055521.1
ncbi gb acc num :
NM_014706.3
ncbi mol weight :
13,773 Da
ncbi summary :
The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]
uniprot summary :
SART3: a ubiquitously expressed protein in proliferating cells. A component of the 7SK snRNP complex composed of P-TEFb (composed of CDK9 and CCNT1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Transiently associates with the U6 and U4/U6 snRNPs during the spliceosome cycle, helping to regenerate functional U4/U6 snRNPs complexes. Expressed in the nucleus of all of malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas, adenocarcinomas, melanomas and leukemias. However, this protein is undetectable in the nucleus of nonmalignant cell lines or normal tissues, except for the testis. Expressed in the cytoplasm of all proliferating cells, including normal and malignant cells, but not in most cells of normal tissues, except for the testis and the fetal liver. Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. 3 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding; Transcription regulation; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 12q24.1. Cellular Component: nucleoplasm; Cajal body; U4/U6 x U5 tri-snRNP complex; cytoplasm; nuclear speck; nucleus. Molecular Function: U4 snRNA binding; protein binding; U6atac snRNA binding; histone binding; nucleotide binding; U6 snRNA binding. Biological Process: nuclear mRNA splicing, via spliceosome; assembly of spliceosomal tri-snRNP; nucleosome assembly; spliceosomal snRNP biogenesis; regulation of gene expression; homeostasis of number of cells; cell morphogenesis. Disease: Porokeratosis 3, Disseminated Superficial Actinic Type
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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