catalog number :
MBS710617
products full name :
Rabbit anti-human A kinase (PRKA) anchor protein 7 polyclonal Antibody
products short name :
A kinase (PRKA) anchor protein 7
products name syn :
A kinase (PRKA) anchor protein 7; AKAP7; AKAP18
other names :
A kinase (PRKA) anchor protein 7, isoform CRA_b; A-kinase anchor protein 7 isoforms alpha and beta; A-kinase anchor protein 7 isoform gamma; AKAP 18; PRKA7 isoform gamma; AKAP-7 isoform gamma; PRKA7 isoforms alpha/beta; A-kinase anchor protein 9 kDa; A-kinase anchor protein 18 kDa; AKAP-7 isoforms alpha and beta; A-kinase anchor protein 7 isoforms alpha and beta; A kinase (PRKA) anchor protein 7; A-kinase anchor protein 18 kDa; AKAP 18; Protein kinase A-anchoring protein 7 isoforms alpha/beta; PRKA7 isoforms alpha/beta
other gene names :
AKAP7; AKAP7; AKAP15; AKAP18; AKAP15; AKAP18; AKAP-7 isoforms alpha and beta; AKAP 18; PRKA7 isoforms alpha/beta
uniprot entry name :
AKA7A_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB)
other info1 :
Immunogen: Human AKAP7
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
EAW48058.1
ncbi mol weight :
39,518 Da
ncbi pathways :
G Protein Signaling Pathways (198849)
ncbi summary :
This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]
uniprot summary :
AKAP7 iso1: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 6q23. Cellular Component: apical plasma membrane; plasma membrane; nucleus; cytosol; lateral plasma membrane. Molecular Function: protein binding; protein kinase A binding; nucleotide binding; protein kinase binding. Biological Process: regulation of action potential; protein localization; ion transport