Rabbit anti-human N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 polyclonal Antibody | MyBioSource MBS710510 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 polyclonal Antibody

catalog :

MBS710510

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS710510

products type :

Antibody

products full name :

Rabbit anti-human N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 polyclonal Antibody

products short name :

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1

products name syn :

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; NDST1; HSST; NST1

other names :

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1, isoform CRA_a; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; NDST-1; HSNST 1; N-HSST 1; N-heparan sulfate sulfotransferase 1; glucosaminyl N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase; [Heparan sulfate]-glucosamine N-sulfotransferase 1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Glucosaminyl N-deacetylase/N-sulfotransferase 1; NDST-1; N-heparan sulfate sulfotransferase 1; N-HSST 1; [Heparan sulfate]-glucosamine N-sulfotransferase 1; HSNST 1

other gene names :

NDST1; NDST1; HSST; NST1; HSST; HSST1; NDST-1; N-HSST 1; HSNST 1

uniprot entry name :

NDST1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

882

purity :

Antigen Affinity Purified

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

other info1 :

Immunogen: Human NDST1

other info2 :

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

ncbi gi num :

119582124

ncbi acc num :

EAW61720.1

ncbi mol weight :

62,065 Da

ncbi pathways :

Disease Pathway (530764); Glycogen Storage Diseases Pathway (980468); Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway (82984); Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway (358); Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway (413365); Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway (468252); Glycosaminoglycan Metabolism Pathway (645297); HS-GAG Biosynthesis Pathway (645306); Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway (645304); MPS I - Hurler Syndrome Pathway (685537)

ncbi summary :

This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

uniprot summary :

NDST1: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response. Belongs to the sulfotransferase 1 family. NDST subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Transferase; Glycan Metabolism - heparan sulfate biosynthesis; Hydrolase; EC 2.8.2.8. Chromosomal Location of Human Ortholog: 5q33.1. Cellular Component: Golgi membrane; integral to membrane. Molecular Function: deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity. Biological Process: smoothened signaling pathway; fibroblast growth factor receptor signaling pathway; glycosaminoglycan metabolic process; MAPKKK cascade; pathogenesis; respiratory gaseous exchange; embryonic viscerocranium morphogenesis; polysaccharide biosynthetic process; glycosaminoglycan biosynthetic process; heparin biosynthetic process; forebrain development; midbrain development; heparan sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; embryonic neurocranium morphogenesis; inflammatory response. Disease: Mental Retardation, Autosomal Recessive 46

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage