product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human ubiquitin protein ligase E3 component n-recognin 2 polyclonal Antibody
catalog :
MBS710390
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS710390
products type :
Antibody
products full name :
Rabbit anti-human ubiquitin protein ligase E3 component n-recognin 2 polyclonal Antibody
products short name :
ubiquitin protein ligase E3 component n-recognin 2
products name syn :
ubiquitin protein ligase E3 component n-recognin 2; UBR2; C6orf133; DKFZp686C08114; KIAA0349; MGC71112; RP3-392M17.3; bA49A4.1; dJ242G1.1; dJ392M17.3
other names :
ubiquitin protein ligase E3 component n-recognin 2, isoform CRA_d; E3 ubiquitin-protein ligase UBR2; E3 ubiquitin-protein ligase UBR2; ubiquitin-protein ligase E3-alpha-2; ubiquitin-protein ligase E3-alpha-II; ubiquitin protein ligase E3 component n-recognin 2; N-recognin-2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II
other gene names :
UBR2; UBR2; C6orf133; bA49A4.1; dJ242G1.1; dJ392M17.3; C6orf133; KIAA0349
uniprot entry name :
UBR2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
277
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
other info1 :
Immunogen: Human UBR2
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi gi num :
119624502
ncbi acc num :
EAX04097.1
ncbi mol weight :
200,540 Da
ncbi pathways :
Adaptive Immune System Pathway (366160); Antigen Processing: Ubiquitination Proteasome Degradation Pathway (366162); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Immune System Pathway (106386)
ncbi summary :
This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
uniprot summary :
UBR2: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Belongs to the UBR1 family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: EC 6.3.2.19; Ligase; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: nucleoplasm; plasma membrane; chromatin; ubiquitin ligase complex. Molecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity. Biological Process: ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; male meiosis I; chromatin silencing; spermatogenesis; histone H2A ubiquitination
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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