Rabbit anti-human carboxyl ester lipase (bile salt-stimulated lipase) polyclonal Antibody | MyBioSource MBS710321 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human carboxyl ester lipase (bile salt-stimulated lipase) polyclonal Antibody

catalog :

MBS710321

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS710321

products type :

Antibody

products full name :

Rabbit anti-human carboxyl ester lipase (bile salt-stimulated lipase) polyclonal Antibody

products short name :

carboxyl ester lipase

products name syn :

carboxyl ester lipase (bile salt-stimulated lipase); CEL; BAL; BSDL; BSSL; CELL; CEase; FAP; FAPP; LIPA; MODY8

other names :

carboxyl ester lipase; Bile salt-activated lipase; bile salt-activated lipase; bucelipase; sterol esterase; cholesterol esterase; carboxyl ester hydrolase; fetoacinar pancreatic protein; lysophospholipase, pancreatic; bile salt-dependent lipase, oncofetal isoform; carboxyl ester lipase (bile salt-stimulated lipase); carboxyl ester lipase; Bile salt-stimulated lipase; BSSL; Bucelipase; Carboxyl ester lipase; Cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase

other gene names :

CEL; CEL; BAL; FAP; BSDL; BSSL; CELL; FAPP; LIPA; CEase; MODY8; BAL; BAL; BSSL

uniprot entry name :

CEL_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human,Mouse; Other species are not tested. Please decide the specificity by homology.

sequence length :

745

purity :

Antigen Affinity Purified

form :

Liquid

storage stability :

Shipped at 4 degre C Upon delivery aliquot and store at -20 degre C or -80 degre C. Avoid repeated freeze.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

ELISA: Use at an assay dependent dilution. WB : 1:500-1:5000 . IF : 1:10-1:100 (Recommender dilutions) . Positive WB detected in: Human liver tissue, HeLa cells, mouse heart tissue, mouse liver tissue . Positive IF detected in: HeLa cells

other info1 :

Immunogen: Human CEL. Conjugate : Non-conjugated

other info2 :

Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

products description :

Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.

ncbi gi num :

180244

ncbi acc num :

AAA51973.1

ncbi pathways :

Acylglycerol Degradation Pathway (413388); Acylglycerol Degradation Pathway (468272); Digestion Of Dietary Lipid Pathway (106112); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Glycerolipid Metabolism Pathway (82986); Glycerolipid Metabolism Pathway (361); Lipid Digestion, Mobilization, And Transport Pathway (106111); Metabolic Pathways (132956); Metabolism Pathway (477135)

ncbi summary :

The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. [provided by RefSeq, Jul 2008]

uniprot summary :

CEL: Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides. Defects in CEL are a cause of maturity-onset diabetes of the young type 8 with exocrine dysfunction (MODY8); also known as diabetes and pancreatic exocrine dysfunction (DPED). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Lipid Metabolism - glycerolipid; EC 3.1.1.13; Secreted, signal peptide; EC 3.1.1.3; Lipid Metabolism - steroid biosynthesis; Lipase; Secreted. Chromosomal Location of Human Ortholog: 9q34.3. Cellular Component: extracellular space; cytoplasm; extracellular region. Molecular Function: heparin binding; sterol esterase activity; triacylglycerol lipase activity; protein binding; hydrolase activity; acylglycerol lipase activity; catalytic activity. Biological Process: intestinal lipid catabolic process; triacylglycerol metabolic process; cholesterol absorption; lipid metabolic process; fatty acid catabolic process; pancreatic juice secretion; protein amino acid esterification; cholesterol catabolic process; lipid digestion. Disease: Maturity-onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage