catalog number :
MBS710232
products full name :
Rabbit anti-human glutaminase polyclonal Antibody
products short name :
glutaminase
products name syn :
glutaminase; GLS; AAD20; DKFZp686O15119; FLJ10358; GLS1; KIAA0838
other names :
glutaminase; Glutaminase liver isoform, mitochondrial; glutaminase liver isoform, mitochondrial; glutaminase I; breast cell glutaminase; L-glutamine amidohydrolase; phosphate-activated glutaminase; phosphate-dependent glutaminase; glutaminase 2 (liver, mitochondrial); L-glutaminase; L-glutamine amidohydrolase
other gene names :
GLS2; GLS2; GA; GLS; LGA; hLGA; GA; GLS
uniprot entry name :
GLSL_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human GLS
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAF21934.1
ncbi mol weight :
23,055 Da
ncbi pathways :
Alanine, Aspartate And Glutamate Metabolism Pathway (101142); Alanine, Aspartate And Glutamate Metabolism Pathway (100063); Amino Acid Synthesis And Interconversion (transamination) Pathway (106173); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); D-Glutamine And D-glutamate Metabolism Pathway (82971); D-Glutamine And D-glutamate Metabolism Pathway (340); GABAergic Synapse Pathway (377263); GABAergic Synapse Pathway (377129); Glutamate Neurotransmitter Release Cycle Pathway (106522)
ncbi summary :
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
uniprot summary :
GLS2: Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. Belongs to the glutaminase family. Protein type: EC 3.5.1.2; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Hydrolase; Energy Metabolism - nitrogen. Chromosomal Location of Human Ortholog: 12q13.3. Cellular Component: mitochondrion; mitochondrial matrix. Molecular Function: protein binding; glutaminase activity. Biological Process: regulation of apoptosis; amino acid metabolic process; synaptic transmission; glutamate secretion; neurotransmitter secretion; glutamine metabolic process; amino acid biosynthetic process