Rabbit anti-human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 polyclonal Antibody | MyBioSource MBS710225 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 polyclonal Antibody

catalog :

MBS710225

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS710225

products type :

Antibody

products full name :

Rabbit anti-human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 polyclonal Antibody

products short name :

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2

products name syn :

ATPase; Ca++ transporting; cardiac muscle; slow twitch 2; ATP2A2; ATP2B; DAR; DD; DKFZp686P0211; FLJ20293; FLJ38063; MGC45367; SERCA2

other names :

ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2; calcium pump 2; SR Ca(2+)-ATPase 2; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase

other gene names :

ATP2A2; ATP2A2; DD; DAR; ATP2B; SERCA2; ATP2B; SERCA2; SR Ca(2+)-ATPase 2

uniprot entry name :

AT2A2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1042

purity :

Antigen Affinity Purified

tested application :

ELISA (EIA), Western Blot (WB)

other info1 :

Immunogen: Human SERCA2,ATP2A2

other info2 :

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

ncbi gi num :

23272583

ncbi acc num :

AAH35588.1

ncbi mol weight :

109,734 Da

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050)

ncbi summary :

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]

uniprot summary :

SERCA2: an intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells. Possesses a Ca(2+)-ATPase activity. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN. Two alternatively spliced isoforms have been described. Protein type: Transporter, ion channel; Membrane protein, integral; Endoplasmic reticulum; Transporter; Cell adhesion; Hydrolase; EC 3.6.3.8; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 12q24.11. Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; sarcoplasmic reticulum; membrane; integral to plasma membrane; endoplasmic reticulum. Molecular Function: protein C-terminus binding; protein binding; enzyme binding; calcium-transporting ATPase activity; metal ion binding; calcium ion binding; ATP binding. Biological Process: cellular calcium ion homeostasis; ER-nuclear signaling pathway; endoplasmic reticulum calcium ion homeostasis; epidermis development; negative regulation of heart contraction; metabolic process; elevation of endoplasmic reticulum calcium ion concentration; positive regulation of heart rate; blood coagulation; cell adhesion; transmembrane transport; regulation of the force of heart contraction. Disease: Acrokeratosis Verruciformis; Darier-white Disease

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage