product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human collagen triple helix repeat containing 1 polyclonal Antibody
catalog :
MBS710022
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS710022
products type :
Antibody
products full name :
Rabbit anti-human collagen triple helix repeat containing 1 polyclonal Antibody
products short name :
collagen triple helix repeat containing 1
products name syn :
collagen triple helix repeat containing 1;
other names :
Collagen triple helix repeat containing 1; Collagen triple helix repeat-containing protein 1; collagen triple helix repeat-containing protein 1; collagen triple helix repeat containing 1; Protein NMTC1
other gene names :
CTHRC1; CTHRC1
uniprot entry name :
CTHR1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
243
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB)
other info1 :
Immunogen: Human CTHRC1
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi gi num :
15559790
ncbi acc num :
AAH14245.1
ncbi mol weight :
24,770 Da
ncbi pathways :
Noncanonical Wnt Signaling Pathway (169354); Wnt Signaling Network Pathway (137962)
ncbi summary :
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
uniprot summary :
CTHRC1: May act as a negative regulator of collagen matrix deposition. Defects in CTHRC1 may be a cause of Barrett esophagus (BE). A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. Genetic variants in CTHRC1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 8q22.3. Cellular Component: extracellular space; proteinaceous extracellular matrix; collagen; cytoplasm. Molecular Function: Wnt-protein binding; frizzled binding. Biological Process: positive regulation of osteoblast differentiation; cell migration; inner ear receptor stereocilium organization and biogenesis; positive regulation of protein binding; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of osteoblast proliferation. Disease: Barrett Esophagus
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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